Etidocaine Hydrochloride | CAS #36637-19-1 (HCl) | Voltage-Gated Sodium Channel Blocking Agent

Etidocaine Hydrochloride
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328911

CAS#: 36637-19-1 (HCl)

Description: Etidocaine Hydrochloride, also known as Duranest and W-19053, is a voltage-gated sodium channel blocking agent used as an anesthetic with prolonged duration of action.

Chemical Structure

Etidocaine Hydrochloride

CAS# 36637-19-1 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 328911
Name: Etidocaine Hydrochloride
CAS#: 36637-19-1 (HCl)
Chemical Formula: C17H30ClN2O
Exact Mass: 0.00
Molecular Weight: 313.890
Elemental Analysis: C, 65.05; H, 9.63; Cl, 11.29; N, 8.92; O, 5.10

Price and Availability

Size	Price	Availability
5mg	USD 450	2 Weeks
25mg	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 36637-18-0 (free base) 36637-19-1 (HCl)

Synonym: Etidocaine Hydrochloride; Duranest; W-19053; W 19053; W19053

IUPAC/Chemical Name: N-(2,6-dimethylphenyl)-2-(ethyl(propyl)-l4-azanyl)butanamide hydrochloride

InChi Key: VLRLCSBNZVEEFY-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H29N2O.ClH/c1-6-12-19(8-3)15(7-2)17(20)18-16-13(4)10-9-11-14(16)5;/h9-11,15,19H,6-8,12H2,1-5H3,(H,18,20);1H

SMILES Code: CCC([NH](CC)CCC)C(NC1=C(C)C=CC=C1C)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 36637-19-1 (Etidocaine Hydrochloride) 36637-18-0 (Etidocaine)

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 313.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rood JP. Etidocaine in dentistry. Anesth Prog. 1989 Jul-Oct;36(4-5):190-1. PMID: 2490028; PMCID: PMC2190675.

2: Bacsik CJ, Swift JQ, Hargreaves KM. Toxic systemic reactions of bupivacaine and etidocaine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jan;79(1):18-23. doi: 10.1016/s1079-2104(05)80067-8. PMID: 7614153.

3: Ruetsch YA, Böni T, Borgeat A. From cocaine to ropivacaine: the history of local anesthetic drugs. Curr Top Med Chem. 2001 Aug;1(3):175-82. doi: 10.2174/1568026013395335. PMID: 11895133.

4: Bennett RG, Robins P. Etidocaine, a new local anesthetic. J Dermatol Surg Oncol. 1979 Jul;5(7):551-3. doi: 10.1111/j.1524-4725.1979.tb00714.x. PMID: 458021.

5: Albright GA. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology. 1979 Oct;51(4):285-7. doi: 10.1097/00000542-197910000-00001. PMID: 484889.

6: Thomas J, Morgan D, Vine J. Metabolism of etidocaine in man. Xenobiotica. 1976 Jan;6(1):39-48. doi: 10.3109/00498257609151610. PMID: 1274369.

7: Munson ES, Tucker WK, Ausinsch B, Malagodi MH. Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys. Anesthesiology. 1975 Apr;42(4):471-8. doi: 10.1097/00000542-197504000-00018. PMID: 1119714.

8: Garcia DG. Etidocaine--a long-acting anesthetic agent. Review of the literature. Anesth Prog. 1982 Jan-Feb;29(1):12-3. PMID: 6954860; PMCID: PMC2515462.

9: Moore DC, Bridenbaugh PO, Bridenbaugh LD, Thompson GE, Balfour RI, Lysons DF. Bupivacaine compared with etidocaine for vaginal delivery. Anesth Analg. 1975 Mar-Apr;54(2):250-6. PMID: 1168435.

10: Morgan DJ, Smyth MP, Thomas J, Vine J. Cyclic metabolites of etidocaine in humans. Xenobiotica. 1977 Jun;7(6):365-75. doi: 10.3109/00498257709035795. PMID: 610053.

11: Willdeck-Lund G, Edström H. Etidocaine in intercostal nerve block for pain relief after thoracotomy; a comparison with bupivacaine. Acta Anaesthesiol Scand Suppl. 1975;60:33-8. doi: 10.1111/j.1399-6576.1975.tb05403.x. PMID: 241197.

12: Oliveira JD, Ribeiro LNM, Rodrigues da Silva GH, Casadei BR, Couto VM, Martinez EF, de Paula E. Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity. Pharm Res. 2018 Oct 10;35(12):229. doi: 10.1007/s11095-018-2512-4. PMID: 30306273.

13: Malamed SF. Nouveaux anesthésiques [New anesthetics]. Rev Belge Med Dent (1984). 2000;55(1):9-18. French. PMID: 11039279.

14: Stanton-Hicks M, Murphy TM, Bonica JJ, Berges PU, Mather LE, Tucker GT. Effects of peridural block: V. Properties, circulatory effects, and blood levels of etidocaine and lidocaine. Anesthesiology. 1975 Apr;42(4):398-407. PMID: 235229.

15: Sisk AL. Analgesic concerns. J Am Dent Assoc. 1990 Aug;121(2):220. doi: 10.14219/jada.archive.1990.0239. PMID: 2401775.

16: Lund PC, Cwik JC, Gannon RT. Etidocaine (Duranest): a clinical and laboratory evaluation. Acta Anaesthesiol Scand. 1974;18(3):176-88. doi: 10.1111/j.1399-6576.1974.tb00858.x. PMID: 4428937.

17: Sinclair CJ, Scott DB. Comparison of bupivacaine and etidocaine in extradural blockade. Br J Anaesth. 1984 Feb;56(2):147-53. doi: 10.1093/bja/56.2.147. PMID: 6362694.

18: Malagodi MH, Munson ES, Embro WJ. Relation of etidocaine and bupivacaine toxicity to rate of infusion in rhesus monkeys. Br J Anaesth. 1977 Feb;49(2):121-5. doi: 10.1093/bja/49.2.121. PMID: 402143.

19: Stanton-Hicks M, Murphy TM, Bonica JJ, Mather LE, Tucker GT. Effects of extradural block: comparison of the properties, circulatory effects and pharmacokinetics of etidocaine and bupivacaine. Br J Anaesth. 1976 Jun;48(6):575-86. doi: 10.1093/bja/48.6.575. PMID: 952693.

20: Donoghue R, Doberenz K, Jacobsen PL. Etidocaine hydrochloride in surgical procedures: effects on postoperative analgesia. J Am Dent Assoc. 1990 Apr;120(4):429-32, 434. doi: 10.14219/jada.archive.1990.0129. PMID: 2319066.

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