Clovoxamine fumarate

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MedKoo CAT#: 328108

CAS#: 54739-21-8 (fumarate)

Description: Clovoxamine, also known as DU 23811, is a nontricyclic antidepressant and has a dual action in blocking the reuptake of both noradrenaline and serotonin. Clovoxamine has little affinity for muscarinic, histaminergic, serotonergic and adrenergic binding sites. Clovoxamine induces a decrease in the functional beta-adrenergic receptor coupled c-AMP response.

Chemical Structure

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Clovoxamine fumarate
CAS# 54739-21-8 (fumarate)
Instruction

Theoretical Analysis

MedKoo Cat#: 328108
Name: Clovoxamine fumarate
CAS#: 54739-21-8 (fumarate)
Chemical Formula: C18H25ClN2O6
Exact Mass: 284.13
Molecular Weight: 400.856
Elemental Analysis: C, 53.93; H, 6.29; Cl, 8.84; N, 6.99; O, 23.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 54739-21-8 (fumarate)   54739-19-4 (free base)  

Synonym: Clovoxamine fumarate; DU 23811; DU-23811; DU23811.

IUPAC/Chemical Name: 4'-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime fumarate

InChi Key: HOFGGHPYWKSXTN-QCHLHFLZSA-N

InChi Code: InChI=1S/C14H21ClN2O2.C4H4O4/c1-18-10-3-2-4-14(17-19-11-9-16)12-5-7-13(15)8-6-12;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,16H2,1H3;1-2H,(H,5,6)(H,7,8)/b17-14+;2-1+

SMILES Code: COCCCC/C(C1=CC=C(Cl)C=C1)=N\OCCN.OC(/C=C/C(O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 400.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jesinger DK, Gostick N. Anxiety neurosis in general practice. A double-blind comparative study of diazepam and clovoxamine, a novel inhibitor of noradrenaline and serotonin reuptake. Int Clin Psychopharmacol. 1989 Oct;4(4):301-11. PubMed PMID: 2691573.

2: Ochs HR, Greenblatt DJ, Verburg-Ochs B, Labedski L. Chronic treatment with fluvoxamine, clovoxamine, and placebo: interaction with digoxin and effects on sleep and alertness. J Clin Pharmacol. 1989 Jan;29(1):91-5. PubMed PMID: 2496149.

3: Saletu B, Grünberger J, Rajna P, Karobath M. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49(1-2):63-86. PubMed PMID: 6777458.

4: Bradford LD, Tulp MT, Schipper J. Biochemical effects in rats after acute and long-term treatment with clovoxamine. Arch Int Pharmacodyn Ther. 1987 Jun;287(2):188-202. PubMed PMID: 2820327.

5: Hurst HE, Jones DR, Wright JH, Jarboe CH. Clovoxamine kinetics in an early clinical trial. Clin Pharmacol Ther. 1983 Aug;34(2):266-71. PubMed PMID: 6872422.

6: Hurst HE, Jones DR, Jarboe CH, deBree H. Determination of clovoxamine concentration in human plasma by electron capture gas chromatography. Clin Chem. 1981 Jul;27(7):1210-2. PubMed PMID: 7237785.

7: Gelenberg AJ, Wojcik JD, Falk WE, Spring B, Brotman AW, Galvin-Nadeau M. Clovoxamine in the treatment of depressed outpatients: a double-blind, parallel-group comparison against amitriptyline and placebo. Compr Psychiatry. 1990 Jul-Aug;31(4):307-14. PubMed PMID: 2201481.

8: Strömberg C, Mattila MJ. Acute comparison of clovoxamine and mianserin, alone and in combination with ethanol, on human psychomotor performance. Pharmacol Toxicol. 1987 May;60(5):374-9. PubMed PMID: 3615347.

9: Minot R, Crocq MA, Roussel B, Marie-Cardine M. [Action of clovoxamine on the sleep of depressed patients. "Polygraphic recordings"]. Encephale. 1985 Mar-Apr;11(2):65-70. French. PubMed PMID: 4017939.

10: de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11. PubMed PMID: 6772658.