GW791343 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526769

CAS#: 1019779-04-4 (HCl)

Description: GW791343 is a P2X7 allosteric modulator. GW791343 exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.

Chemical Structure

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GW791343 HCl
CAS# 1019779-04-4 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 526769
Name: GW791343 HCl
CAS#: 1019779-04-4 (HCl)
Chemical Formula: C20H27Cl3F2N4O
Exact Mass: 0.00
Molecular Weight: 483.810
Elemental Analysis: C, 49.65; H, 5.63; Cl, 21.98; F, 7.85; N, 11.58; O, 3.31

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 309712-55-8 (HCl)   1019779-04-4 (HCl)   309712-73-0 (free base)    

Synonym: GW791343; GW 791343; GW-791343; GW791343 trihydrochloride; GW791343 HCl.

IUPAC/Chemical Name: 2-((3,4-difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide trihydrochloride

InChi Key: WSBRAHWNJBXXJM-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H24F2N4O.3ClH/c1-14-2-3-15(13-26-8-6-23-7-9-26)10-19(14)25-20(27)12-24-16-4-5-17(21)18(22)11-16;;;/h2-5,10-11,23-24H,6-9,12-13H2,1H3,(H,25,27);3*1H

SMILES Code: CC1=C(C=C(C=C1)CN2CCNCC2)NC(=O)CNC3=CC(=C(C=C3)F)F.Cl.Cl.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 483.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Habermacher C, Dunning K, Chataigneau T, Grutter T. Molecular structure and
function of P2X receptors. Neuropharmacology. 2016 May;104:18-30. doi:
10.1016/j.neuropharm.2015.07.032. Epub 2015 Jul 29. Review. PubMed PMID:
26231831.


2: Michel AD, Ng SW, Roman S, Clay WC, Dean DK, Walter DS. Mechanism of action of
species-selective P2X(7) receptor antagonists. Br J Pharmacol. 2009
Apr;156(8):1312-25. doi: 10.1111/j.1476-5381.2009.00135.x. Epub 2009 Mar 20.
PubMed PMID: 19309360; PubMed Central PMCID: PMC2697735.


3: Michel AD, Clay WC, Ng SW, Roman S, Thompson K, Condreay JP, Hall M, Holbrook
J, Livermore D, Senger S. Identification of regions of the P2X(7) receptor that
contribute to human and rat species differences in antagonist effects. Br J
Pharmacol. 2008 Nov;155(5):738-51. doi: 10.1038/bjp.2008.306. Epub 2008 Jul 28.
PubMed PMID: 18660826; PubMed Central PMCID: PMC2584934.


4: Michel AD, Chambers LJ, Walter DS. Negative and positive allosteric modulators
of the P2X(7) receptor. Br J Pharmacol. 2008 Feb;153(4):737-50. Epub 2007 Dec 10.
PubMed PMID: 18071294; PubMed Central PMCID: PMC2259211.