CB-30865

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526714

CAS#: 206275-15-2

Description: CB-30865, also known as ZM 242421, is a potent and selective inhibitors of nicotinamide phosphoribosyltransferase (Nampt) with potential anticancer activity.

Chemical Structure

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CB-30865
CAS# 206275-15-2
Instruction

Theoretical Analysis

MedKoo Cat#: 526714
Name: CB-30865
CAS#: 206275-15-2
Chemical Formula: C26H22BrN5O2
Exact Mass: 515.10
Molecular Weight: 516.399
Elemental Analysis: C, 60.47; H, 4.29; Br, 15.47; N, 13.56; O, 6.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CB-30865; CB 30865; CB30865; ZM 242421; ZM242421; ZM-242421.

IUPAC/Chemical Name: 4-(((7-bromo-2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-yn-1-yl)amino)-N-(pyridin-3-ylmethyl)benzamide

InChi Key: SHNBLWMBWXIKMR-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H22BrN5O2/c1-3-11-32(16-20-12-22-24(13-23(20)27)30-17(2)31-26(22)34)21-8-6-19(7-9-21)25(33)29-15-18-5-4-10-28-14-18/h1,4-10,12-14H,11,15-16H2,2H3,(H,29,33)(H,30,31,34)

SMILES Code: O=C(NCC1=CC=CN=C1)C2=CC=C(N(CC3=CC4=C(NC(C)=NC4=O)C=C3Br)CC#C)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 516.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lockman JW, Murphy BR, Zigar DF, Judd WR, Slattum PM, Gao ZH, Ostanin K, Green
J, McKinnon R, Terry-Lorenzo RT, Fleischer TC, Boniface JJ, Shenderovich M,
Willardsen JA. Analogues of
4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridy
lmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide
phosphoribosyltransferase (Nampt). J Med Chem. 2010 Dec 23;53(24):8734-46. doi:
10.1021/jm101145b. Epub 2010 Nov 16. PubMed PMID: 21080724.


2: Fleischer TC, Murphy BR, Flick JS, Terry-Lorenzo RT, Gao ZH, Davis T, McKinnon
R, Ostanin K, Willardsen JA, Boniface JJ. Chemical proteomics identifies Nampt as
the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun
25;17(6):659-64. doi: 10.1016/j.chembiol.2010.05.008. PubMed PMID: 20609415.


3: Bavetsias V, Skelton LA, Yafai F, Mitchell F, Wilson SC, Allan B, Jackman AL.
The design and synthesis of water-soluble analogues of CB30865, a
quinazolin-4-one-based antitumor agent. J Med Chem. 2002 Aug 15;45(17):3692-702.
PubMed PMID: 12166942.


4: Hiorns LR, Seckl MJ, Paradinas F, Sharp SY, Skelton LA, Brunstrom G, Newlands
ES, Kelland LR, Leyland-Jones B. A molecular cytogenetic approach to studying
platinum resistance. J Inorg Biochem. 1999 Oct;77(1-2):95-104. PubMed PMID:
10626360.