Cyantraniliprole
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MedKoo CAT#: 326648

CAS#: 736994-63-1

Description: Cyantraniliprole is a novel second-generation anthranilic diamide insecticide which has been shown to deter insect feeding and reduce disease transmission. Cyantraniliprol is a valuable tool for Frankliniella occidentalis (Pergande) management. Cyantraniliprole is as effective as abamectin in deterring potato psyllid feeding and could significantly reduce transmission of Lso and the spread of ZC.

Chemical Structure

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Cyantraniliprole
CAS# 736994-63-1
Instruction

Theoretical Analysis

MedKoo Cat#: 326648
Name: Cyantraniliprole
CAS#: 736994-63-1
Chemical Formula: C19H14BrClN6O2
Exact Mass: 472.01
Molecular Weight: 473.715
Elemental Analysis: C, 48.17; H, 2.98; Br, 16.87; Cl, 7.48; N, 17.74; O, 6.75

Price and Availability

Size Price Availability Quantity
100mg USD 750
200mg USD 1250
500mg USD 2150
1g USD 2950
2g USD 3950
5g USD 6450
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Synonym: Cyantraniliprole

IUPAC/Chemical Name: 3-bromo-1-(3-chloro-2-pyridinyl)-N-(4-cyano-2-methyl-6-((methylamino)carbonyl)phenyl)-1H-pyrazole-5-carboxamide

InChi Key: DVBUIBGJRQBEDP-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H14BrClN6O2/c1-10-6-11(9-22)7-12(18(28)23-2)16(10)25-19(29)14-8-15(20)26-27(14)17-13(21)4-3-5-24-17/h3-8H,1-2H3,(H,23,28)(H,25,29)

SMILES Code: O=C(C1=CC(Br)=NN1C2=NC=CC=C2Cl)NC3=C(C(NC)=O)C=C(C#N)C=C3C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 473.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Selby TP, Lahm GP, Stevenson TM. A Retrospective Look at Anthranilic Diamide Insecticides: Discovery and Lead Optimization to Chlorantraniliprole and Cyantraniliprole. Pest Manag Sci. 2016 May 5. doi: 10.1002/ps.4308. [Epub ahead of print] PubMed PMID: 27146435.

2: Bird LJ. Susceptibility of Helicoverpa armigera (Lepidoptera: Noctuidae) to Cyantraniliprole Determined From Topical and Ingestion Bioassays. J Econ Entomol. 2016 Feb 25. pii: tow027. [Epub ahead of print] PubMed PMID: 26921229.

3: Parker C, Baldwin R, Pereira R, Koehler P. Evaluation of Cyantraniliprole and Other Commercial Fly Baits under Laboratory and Field Conditions. Insects. 2015 Nov 23;6(4):977-87. doi: 10.3390/insects6040977. PubMed PMID: 26610575; PubMed Central PMCID: PMC4693182.

4: Caballero R, Schuster DJ, Peres NA, Mangandi J, Hasing T, Trexler F, Kalb S, Portillo HE, Marçon PC, Annan IB. Effectiveness of Cyantraniliprole for Managing Bemisia tabaci (Hemiptera: Aleyrodidae) and Interfering with Transmission of Tomato Yellow Leaf Curl Virus on Tomato. J Econ Entomol. 2015 Jun;108(3):894-903. doi: 10.1093/jee/tou034. Epub 2015 May 4. PubMed PMID: 26470209.

5: Ammar el-D, Hall DG, Alvarez JM. Effect of Cyantraniliprole, a Novel Insecticide, on the Inoculation of Candidatus Liberibacter Asiaticus Associated with Citrus Huanglongbing by the Asian Citrus Psyllid (Hemiptera: Liviidae). J Econ Entomol. 2015 Apr;108(2):399-404. doi: 10.1093/jee/tov016. Epub 2015 Feb 13. PubMed PMID: 26470150.

6: Mustafa T, Alvarez JM, Munyaneza JE. Effect of Cyantraniliprole on Probing Behavior of the Potato Psyllid (Hemiptera: Triozidae) as Measured by the Electrical Penetration Graph Technique. J Econ Entomol. 2015 Dec;108(6):2529-35. doi: 10.1093/jee/tov259. Epub 2015 Sep 2. PubMed PMID: 26340224.

7: Sang S, Shu B, Yi X, Liu J, Hu M, Zhong G. Cross-resistance and baseline susceptibility of Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae) to cyantraniliprole in the south of China. Pest Manag Sci. 2016 May;72(5):922-8. doi: 10.1002/ps.4068. Epub 2015 Jul 23. PubMed PMID: 26118543.

8: Li QF, Li X, Hunag JB, Zhang DM, Yuan JZ. Efficacy of cyantraniliprole fly bait against housefly (Musca domestica L.) under laboratory conditions. Parasitol Res. 2015 Sep;114(9):3525-8. doi: 10.1007/s00436-015-4584-y. Epub 2015 Jun 26. PubMed PMID: 26113508.

9: Pan X, Dong F, Xu J, Liu X, Chen Z, Liu N, Chen X, Tao Y, Zhang H, Zheng Y. Simultaneous determination of chlorantraniliprole and cyantraniliprole in fruits, vegetables and cereals using ultra-high-performance liquid chromatography-tandem mass spectrometry with the isotope-labelled internal standard method. Anal Bioanal Chem. 2015 May;407(14):4111-20. doi: 10.1007/s00216-015-8603-8. Epub 2015 Mar 31. PubMed PMID: 25822158.

10: Farkas I, Molnár I, Somlyay I, Tóth E. EFFICACY DATA OF CYANTRANILIPROLE CONTAINING INSECTICIDE PREPARATION ON CABBAGE ROOT FLY (DELIA RADICUM LINNAEUS) IN WINTER OILSEED RAPE. Commun Agric Appl Biol Sci. 2015;80(2):149-52. PubMed PMID: 27145579.

11: Bielza P, Guillén J. Cyantraniliprole: a valuable tool for Frankliniella occidentalis (Pergande) management. Pest Manag Sci. 2015 Aug;71(8):1068-74. doi: 10.1002/ps.3886. Epub 2014 Sep 15. PubMed PMID: 25138907.

12: Grávalos C, Fernández E, Belando A, Moreno I, Ros C, Bielza P. Cross-resistance and baseline susceptibility of Mediterranean strains of Bemisia tabaci to cyantraniliprole. Pest Manag Sci. 2015 Jul;71(7):1030-6. doi: 10.1002/ps.3885. Epub 2014 Sep 15. PubMed PMID: 25138719.

13: Zhang R, He S, Chen J. Monitoring of Bactrocera dorsalis (Diptera: Tephritidae) resistance to cyantraniliprole in the south of China. J Econ Entomol. 2014 Jun;107(3):1233-8. PubMed PMID: 25026687.

14: Civolani S, Cassanelli S, Chicca M, Rison JL, Bassi A, Alvarez JM, Annan IB, Parrella G, Giorgini M, Fano EA. An EPG study of the probing behavior of adult Bemisia tabaci biotype Q (Hemiptera: Aleyrodidae) following exposure to cyantraniliprole. J Econ Entomol. 2014 Jun;107(3):910-9. PubMed PMID: 25026647.

15: Murillo AC, Gerry AC, Gallagher NT, Peterson NG, Mullens BA. Laboratory and field assessment of cyantraniliprole relative to existing fly baits. Pest Manag Sci. 2015 May;71(5):752-8. doi: 10.1002/ps.3847. Epub 2014 Jul 15. PubMed PMID: 24976618.

16: Sharma AK, Zimmerman WT, Singles SK, Malekani K, Swain S, Ryan D, Mcquorcodale G, Wardrope L. Photolysis of chlorantraniliprole and cyantraniliprole in water and soil: verification of degradation pathways via kinetics modeling. J Agric Food Chem. 2014 Jul 16;62(28):6577-84. doi: 10.1021/jf5017175. Epub 2014 Jul 7. PubMed PMID: 24971760.

17: Cameron R, Lang EB, Alvarez JM. Use of honeydew production to determine reduction in feeding by Bemisia tabaci (Hemiptera: Aleyrodidae) adults when exposed to cyantraniliprole and imidacloprid treatments. J Econ Entomol. 2014 Apr;107(2):546-50. PubMed PMID: 24772533.

18: Barry JD, Portillo HE, Annan IB, Cameron RA, Clagg DG, Dietrich RF, Watson LJ, Leighty RM, Ryan DL, McMillan JA, Swain RS, Kaczmarczyk RA. Movement of cyantraniliprole in plants after foliar applications and its impact on the control of sucking and chewing insects. Pest Manag Sci. 2015 Mar;71(3):395-403. doi: 10.1002/ps.3816. Epub 2014 May 27. PubMed PMID: 24771486.

19: Zhang R, Jang EB, He S, Chen J. Lethal and sublethal effects of cyantraniliprole on Bactrocera dorsalis (Hendel) (Diptera: Tephritidae). Pest Manag Sci. 2015 Feb;71(2):250-6. doi: 10.1002/ps.3791. Epub 2014 May 27. PubMed PMID: 24700426.

20: Sharma AK, Zimmerman WT, Lowrie C, Chapleo S. Hydrolysis of chlorantraniliprole and cyantraniliprole in various pH buffer solutions. J Agric Food Chem. 2014 Apr 23;62(16):3531-6. doi: 10.1021/jf500671w. Epub 2014 Apr 9. PubMed PMID: 24694259.