LASSBio-881

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522702

CAS#: unknown

Description: LASSBio-881 is a drug which acts as both a non-selective partial agonist of the CB1 and CB2 cannabinoid receptors, and also as an antagonist of the TRPV1 receptor, as well as having antioxidant effects. It has potent anti-inflammatory and anti-hyperalgesic effects in animal studies.

Chemical Structure

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LASSBio-881
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 522702
Name: LASSBio-881
CAS#: unknown
Chemical Formula: C23H27N3O6
Exact Mass: 441.19
Molecular Weight: 441.484
Elemental Analysis: C, 62.57; H, 6.16; N, 9.52; O, 21.74

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: LASSBio-881; LASSBio 881; LASSBio881.

IUPAC/Chemical Name: N'-[(3,5-ditert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-6-nitro-1,3-benzodioxole-5-carbohydrazide

InChi Key: YLCSFBMOLIJBHG-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H27N3O6/c1-22(2,3)15-7-13(8-16(20(15)27)23(4,5)6)11-24-25-21(28)14-9-18-19(32-12-31-18)10-17(14)26(29)30/h7-11,24H,12H2,1-6H3,(H,25,28)

SMILES Code: O=C(C1=C([N+]([O-])=O)C=C(OCO2)C2=C1)NN/C=C3C=C(C(C)(C)C)C(C(C(C)(C)C)=C/3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 441.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Salat K, Moniczewski A, Librowski T. Nitrogen, oxygen or sulfur containing
heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative
stress. Mini Rev Med Chem. 2013 Mar;13(3):335-52. Review. PubMed PMID: 22876956.


2: Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, Duarte CD,
Barreiro EJ, Fraga CA, Castro NG, Miranda AL, Guimaraes MZ. LASSBio-881: an
N-acylhydrazone transient receptor potential vanilloid subfamily type 1
antagonist orally effective against the hypernociception induced by capsaicin or
partial sciatic ligation. Br J Pharmacol. 2010 Apr;159(8):1716-23. PubMed PMID:
20401963; PubMed Central PMCID: PMC2925494.


3: Duarte CD, Tributino JL, Lacerda DI, Martins MV, Alexandre-Moreira MS, Dutra
F, Bechara EJ, De-Paula FS, Goulart MO, Ferreira J, Calixto JB, Nunes MP, Bertho
AL, Miranda AL, Barreiro EJ, Fraga CA. Synthesis, pharmacological evaluation and
electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone
derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors.
Bioorg Med Chem. 2007 Mar 15;15(6):2421-33. Epub 2007 Jan 17. PubMed PMID:
17275312.