WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317986
Description: Halofantrine hydrochloride is a blocker of delayed rectifier potassium current via the inhibition of hERG channel. It is an inhibitor of the hERG channel.
MedKoo Cat#: 317986
Name: Halofantrine hydrochloride
Chemical Formula: C26H31Cl3F3NO
Molecular Weight: 536.88
Elemental Analysis: C, 58.16; H, 5.82; Cl, 19.81; F, 10.62; N, 2.61; O, 2.98
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Halofantrine hydrochloride; Halfan; Halofantrine HCl; Halofantrino [Spanish]; WR 171669; WR-171,669; WR-171699; halofantrine;
IUPAC/Chemical Name: 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol;hydrochloride
InChi Key: WANGFTDWOFGECH-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H
SMILES Code: CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 536.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Khoo SM, Prankerd RJ, Edwards GA, Porter CJ, Charman WN. A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs. J Pharm Sci. 2002 Mar;91(3):647-59. PubMed PMID: 11920750.
2: Del Nero L, Lamizana L, Nebie I, Sare S, Bougouma L, Pietra V. In vivo sensitivity of Plasmodium falciparum to halofantrine hydrochloride in Burkina Faso. Am J Trop Med Hyg. 1994 Jan;50(1):102-6. PubMed PMID: 8304564.
3: Gillespie SH, Msaki EP, Ramsay A, Ngowi FI, Fox R. A new micronized formulation of halofantrine hydrochloride in the treatment of acute Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg. 1993 Jul-Aug;87(4):467-9. PubMed PMID: 8249083.
4: Khan MA, Rehman GN, Qazi SA. Halofantrine hydrochloride--efficacy and safety in children with acute malaria. J Pak Med Assoc. 1991 Jan;41(1):8-10. PubMed PMID: 1900550.