Clevidipine
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317541

CAS#: 167221-71-8

Description: Clevidipine is a dihydropyridine L-type calcium channel blocker, highly selective for vascular, as opposed to myocardial, smooth muscle and, therefore, has little or no effect on myocardial contractility or cardiac conduction. It reduces mean arterial blood pressure by decreasing systemic vascular resistance. Clevidipine does not reduce cardiac filling pressure, confirming lack of effects on the venous capacitance vessels. No increase in myocardial lactate production in coronary sinus blood has been seen, confirming the absence of myocardial ischemia due to coronary steal.

Chemical Structure

img
Clevidipine
CAS# 167221-71-8
Instruction

Theoretical Analysis

MedKoo Cat#: 317541
Name: Clevidipine
CAS#: 167221-71-8
Chemical Formula: C21H23Cl2NO6
Exact Mass: 0.00
Molecular Weight: 456.320
Elemental Analysis: C, 55.27; H, 5.08; Cl, 15.54; N, 3.07; O, 21.04

Price and Availability

Size Price Availability Quantity
250mg USD 450
500mg USD 950
1g USD 1650
Bulk inquiry

Synonym: Clevidipine; Clevidipine butyrate; Cleviprex; 167221-71-8; Clevelox; Rac-Clevidipine;

IUPAC/Chemical Name: methyl 5-{[(butanoyloxy)methoxy]carbonyl}-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

InChi Key: KPBZROQVTHLCDU-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3

SMILES Code: CCCC(=O)OCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 456.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Zhou Y, Zhou F, Yan F, Yang F, Yao Y, Zou Q. Structural Analysis and
Quantitative Determination of Clevidipine Butyrate Impurities Using an Advanced
RP-HPLC Method. J Chromatogr Sci. 2015 Oct 21. pii: bmv148. [Epub ahead of print]
PubMed PMID: 26489435.


2: Lemkuil BP, Gierl BT, Patel PM, Pearn ML, Nguyen LC, Minokadeh A, Drummond JC.
The Effect of Clevidipine on Cerebral Blood Flow Velocity and Carbon Dioxide
Reactivity in Human Volunteers. J Neurosurg Anesthesiol. 2015 Oct 6. [Epub ahead
of print] PubMed PMID: 26447497.


3: Zhou Y, Zou Q, Sun L, Wei P, Ouyang P. Determination of clevidipine and its
primary metabolite in rat plasma by a dispersive liquid-liquid microextraction
method. J Chromatogr Sci. 2015 May-Jun;53(5):830-5. doi: 10.1093/chromsci/bmu100.
Epub 2014 Dec 5. PubMed PMID: 25480456.


4: Kako H, Gable A, Martin D, Beebe A, Thung A, Samora W, Klamar J, Bhalla T,
Tobias JD. A prospective, open-label trial of clevidipine for controlled
hypotension during posterior spinal fusion. J Pediatr Pharmacol Ther. 2015
Jan-Feb;20(1):54-60. doi: 10.5863/1551-6776-20.1.54. PubMed PMID: 25859171;
PubMed Central PMCID: PMC4353201.


5: Zhou Y, He XM, Li HQ, Ni Y, Xu MZ, Chen H, Li WY. Pharmacokinetics and tissue
distribution of clevidipine and its metabolite in dogs and rats. J Huazhong Univ
Sci Technolog Med Sci. 2014 Dec;34(6):856-60. doi: 10.1007/s11596-014-1364-3.
Epub 2014 Dec 6. PubMed PMID: 25480581.


6: Zuleta-Alarcón A, Castellón-Larios K, Bergese S. [The role of clevidipine in
hypertension management: clinical results]. Rev Esp Anestesiol Reanim. 2014
Dec;61(10):557-64. doi: 10.1016/j.redar.2014.06.006. Epub 2014 Sep 16. Spanish.
PubMed PMID: 25236947.


7: Wei H, Gu Y, Liu Y, Chen Y, Liu C, Si D. Quantitation of clevidipine in dog
blood by liquid chromatography tandem mass spectrometry: application to a
pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov
15;971:52-7. doi: 10.1016/j.jchromb.2014.09.019. Epub 2014 Sep 29. PubMed PMID:
25270056.


8: Zhou Y, Li H, He X, Jia M, Ni Y, Xu M, Chen H, Li W. Simultaneous
determination of clevidipine and its primary metabolite in dog plasma by liquid
chromatography-tandem mass spectrometry: Application to pharmacokinetic study. J
Pharm Biomed Anal. 2014 Nov;100:294-9. doi: 10.1016/j.jpba.2014.08.018. Epub 2014
Aug 17. PubMed PMID: 25194342.


9: Cao P, Li G, Huang L, Zhao S, Hu Y, Qin L, Qiu L, Zhu W, Si L, Huang J.
Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary
metabolite in dog whole blood. Bioanalysis. 2015;7(12):1457-69. doi:
10.4155/bio.15.74. PubMed PMID: 26168253.


10: Clevidipine. Hypertensive crises during surgery: no advance. Prescrire Int.
2014 Oct;23(153):236. PubMed PMID: 25964966.


11: Keating GM. Clevidipine: a review of its use for managing blood pressure in
perioperative and intensive care settings. Drugs. 2014 Oct;74(16):1947-60. doi:
10.1007/s40265-014-0313-6. Review. PubMed PMID: 25312594.


12: Croft K, Probst S. Deliberate hypotensive anesthesia with the rapidly acting,
vascular-selective, L-type calcium channel antagonist-clevidipine: a case report.
Anesth Prog. 2014 Spring;61(1):18-20. doi: 10.2344/0003-3006-61.1.18. PubMed
PMID: 24697821; PubMed Central PMCID: PMC3975609.


13: Varelas PN, Abdelhak T, Corry JJ, James E, Rehman MF, Schultz L, Mays-Wilson
K, Mitsias P. Clevidipine for acute hypertension in patients with subarachnoid
hemorrhage: a pilot study. Int J Neurosci. 2014 Mar;124(3):192-8. doi:
10.3109/00207454.2013.836703. Epub 2013 Sep 24. PubMed PMID: 24007334.


14: Merry AF, Avery EG, Nussmeier NA, Playford HR, Warman GR, Wang Y, Sladen RN.
Clevidipine compared with nitroglycerin for blood pressure control in coronary
artery bypass grafting: a randomized double-blind study. Can J Anaesth. 2014
May;61(5):398-406. doi: 10.1007/s12630-014-0131-z. Epub 2014 Apr 4. PubMed PMID:
24700403.


15: Peacock WF, Chandra A, Char D, Collins S, Der Sahakian G, Ding L, Dunbar L,
Fermann G, Fonarow GC, Garrison N, Hu MY, Jourdain P, Laribi S, Levy P, Möckel M,
Mueller C, Ray P, Singer A, Ventura H, Weiss M, Mebazaa A. Clevidipine in acute
heart failure: Results of the A Study of Blood Pressure Control in Acute Heart
Failure-A Pilot Study (PRONTO). Am Heart J. 2014 Apr;167(4):529-36. doi:
10.1016/j.ahj.2013.12.023. Epub 2014 Jan 15. PubMed PMID: 24655702.


16: Kurnutala LN, Soghomonyan S, Bergese SD. Perioperative acute
hypertension-role of Clevidipine butyrate. Front Pharmacol. 2014 Aug 27;5:197.
doi: 10.3389/fphar.2014.00197. eCollection 2014. PubMed PMID: 25221513; PubMed
Central PMCID: PMC4145348.


17: Bettesworth JG, Martin DP, Tobias JD. Intraoperative use of clevidipine in a
patient with von Hippel-Lindau disease with associated pheochromocytoma. J
Cardiothorac Vasc Anesth. 2013 Aug;27(4):749-51. doi: 10.1053/j.jvca.2011.12.005.
Epub 2012 Feb 1. PubMed PMID: 22305918.


18: Hassanain HH, Hassona MD, Puente EG, Sun C, Abouelnaga ZA, Tulman DB, Bergese
SD. In vitro assessment of clevidipine using the profilin1 hypertensive mouse
model. Pharmaceuticals (Basel). 2013 Apr 29;6(5):623-33. doi: 10.3390/ph6050623.
PubMed PMID: 24276170; PubMed Central PMCID: PMC3817727.


19: Tobias JD, Tulman DB, Bergese SD. Clevidipine for perioperative blood
pressure control in infants and children. Pharmaceuticals (Basel). 2013 Jan
15;6(1):70-84. doi: 10.3390/ph6010070. PubMed PMID: 24275788; PubMed Central
PMCID: PMC3816677.


20: Graffagnino C, Bergese S, Love J, Schneider D, Lazaridis C, LaPointe M, Lee
K, Lynch G, Hu MY, Williams GC. Clevidipine rapidly and safely reduces blood
pressure in acute intracerebral hemorrhage: the ACCELERATE trial. Cerebrovasc
Dis. 2013;36(3):173-80. doi: 10.1159/000351149. Epub 2013 Oct 12. PubMed PMID:
24135526.