Cinolazepam | CAS#75696-02-5 | benzodiazepine

Cinolazepam
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317533

CAS#: 75696-02-5

Description: Cinolazepam is a benzodiazepine derivative drug. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Due to its strong sedative properties, it is primarily used as an hypnotic.

Chemical Structure

Cinolazepam

CAS# 75696-02-5

Instruction

Theoretical Analysis

MedKoo Cat#: 317533
Name: Cinolazepam
CAS#: 75696-02-5
Chemical Formula: C18H13ClFN3O2
Exact Mass: 357.07
Molecular Weight: 357.770
Elemental Analysis: C, 60.43; H, 3.66; Cl, 9.91; F, 5.31; N, 11.75; O, 8.94

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 800	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Cinolazepam; Gerodorm; OX-373;

IUPAC/Chemical Name: 3-[7-chloro-5-(2-fluorophenyl)-3-hydroxy-2-oxo-3H-1,4-benzodiazepin-1-yl]propanenitrile

InChi Key: XAXMYHMKTCNRRZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H13ClFN3O2/c19-11-6-7-15-13(10-11)16(12-4-1-2-5-14(12)20)22-17(24)18(25)23(15)9-3-8-21/h1-2,4-7,10,17,24H,3,9H2

SMILES Code: C1=CC=C(C(=C1)C2=NC(C(=O)N(C3=C2C=C(C=C3)Cl)CCC#N)O)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 357.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Saletu B, Kindshofer G, Anderer P, Grünberger J. Short-term sleep laboratory
studies with cinolazepam in situational insomnia induced by traffic noise. Int J
Clin Pharmacol Res. 1987;7(5):407-18. PubMed PMID: 2889679.

2: Oelschläger H, Volke J, Belal F. Analysis of drugs by polarography, XXXV: The
polarographic behaviour of
cinolazepam[1-(2-cyanoethyl)-7-chloro-3-hydroxy-5-(2-fluorophe n
yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one] and assay of its tablets. Arch Pharm
(Weinheim). 1992 Feb;325(2):65-8. PubMed PMID: 1605717.

3: Richards BL, Whittle SL, Buchbinder R. Muscle relaxants for pain management in
rheumatoid arthritis. Cochrane Database Syst Rev. 2012 Jan 18;1:CD008922. doi:
10.1002/14651858.CD008922.pub2. Review. PubMed PMID: 22258993.

4: Walash MI, Belal F, Metwally ME, Hefnawy MM. A selective fluorimetric method
for the determination of some 1,4-benzodiazepine drugs containing a hydroxyl
group at C-3. J Pharm Biomed Anal. 1994 Nov;12(11):1417-23. PubMed PMID: 7849137.

5: Mascher H, Nitsche V, Schütz H. Separation, isolation and identification of
optical isomers of 1,4-benzodiazepine glucuronides from biological fluids by
reversed-phase high-performance liquid chromatography. J Chromatogr. 1984 Mar
9;306:231-9. PubMed PMID: 6715462.

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Cinolazepam featured