AZ9482
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407207

CAS#: 1825345-33-2

Description: AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18 nM). Encouragingly, AZ9482 also showed a 3 nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with published siRNA knockdown experiments, AZ9482 was a 9 nM enzyme inhibitor of tankyrase 1 (TNKS1).

Chemical Structure

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AZ9482
CAS# 1825345-33-2
Instruction

Theoretical Analysis

MedKoo Cat#: 407207
Name: AZ9482
CAS#: 1825345-33-2
Chemical Formula: C26H22N6O2
Exact Mass: 450.18
Molecular Weight: 450.502
Elemental Analysis: C, 69.32; H, 4.92; N, 18.66; O, 7.10

Price and Availability

Size Price Availability Quantity
1mg USD 235 2 Weeks
5mg USD 470 2 Weeks
10mg USD 725 2 Weeks
25mg USD 1150 2 Weeks
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Synonym: AZ9482; AZ-9482; AZ 9482.

IUPAC/Chemical Name: 2-(4-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile

InChi Key: ZDDPBFWHZOJFHF-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H22N6O2/c27-17-20-7-4-10-28-24(20)31-11-13-32(14-12-31)26(34)19-6-3-5-18(15-19)16-23-21-8-1-2-9-22(21)25(33)30-29-23/h1-10,15H,11-14,16H2,(H,30,33)

SMILES Code: O=C1NN=C(CC2=CC=CC(C(N3CCN(C4=NC=CC=C4C#N)CC3)=O)=C2)C5=CC=CC=C51

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 450.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Jeffrey W. Johannes, Lynsie Almeida, Kevin Daly, Andrew D. Ferguson, Shaun E. Grosskurth, Huiping Guan, Tina Howard, Stephanos Ioannidis, Steven Kazmirski, Michelle L. Lamb, Nicholas A. Larsen, Paul D. Lyne, Keith Mikule, Claude Ogoe, Bo Peng, Philip Petteruti, Jon A. Read, Nancy Su, Mark Sylvester, Scott Throner, Wenxian Wang, et al. Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering
In Press, Corrected Proof, Available online 27 October 2015. Bioorg. Med. Chem . Lett. 2015.