QNZ46
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MedKoo CAT#: 522398

CAS#: 1237744-13-6

Description: QNZ46 is an NMDA receptor antagonist. QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit. QNZ46 could provide an opportunity for the development of pharmacological tools and therapeutic agents that target NMDA receptors at a new site and modulate function by a novel mechanism. NMDA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in several neurological diseases.

Chemical Structure

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QNZ46
CAS# 1237744-13-6
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 522398
Name: QNZ46
CAS#: 1237744-13-6
Chemical Formula: C24H17N3O6
Exact Mass: 443.11
Molecular Weight: 443.420
Elemental Analysis: C, 65.01; H, 3.86; N, 9.48; O, 21.65

Price and Availability

Size Price Availability Quantity
10mg USD 150 Ready to ship
25mg USD 250 Ready to ship
50mg USD 450 Ready to ship
100mg USD 650 Ready to ship
200mg USD 950 Ready to ship
500mg USD 1650 Ready to ship
1g USD 2650 Ready to ship
2g USD 4770 Ready to ship
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Synonym: QNZ46; QNZ-46; QNZ 46.

IUPAC/Chemical Name: (E)-4-(6-methoxy-2-(3-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid

InChi Key: GNLVJIICVWDSNI-LFYBBSHMSA-N

InChi Code: InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+

SMILES Code: O=C(O)C1=CC=C(N2C(/C=C/C3=CC=CC([N+]([O-])=O)=C3)=NC4=C(C=C(OC)C=C4)C2=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively).
In vitro activity: QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit. Reference: J Neurosci. 2011 Mar 9;31(10):3650-61. https://pubmed.ncbi.nlm.nih.gov/21389220/
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.5 10.07

Preparing Stock Solutions

The following data is based on the product molecular weight 443.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Hansen KB, Traynelis SF. Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci. 2011 Mar 9;31(10):3650-61. doi: 10.1523/JNEUROSCI.5565-10.2011. PMID: 21389220; PMCID: PMC3063124.
In vitro protocol: 1. Hansen KB, Traynelis SF. Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci. 2011 Mar 9;31(10):3650-61. doi: 10.1523/JNEUROSCI.5565-10.2011. PMID: 21389220; PMCID: PMC3063124.
In vivo protocol: TBD

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1: Hansen KB, Traynelis SF. Structural and mechanistic determinants of a novel
site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J
Neurosci. 2011 Mar 9;31(10):3650-61. doi: 10.1523/JNEUROSCI.5565-10.2011. PubMed
PMID: 21389220; PubMed Central PMCID: PMC3063124.

1. Hansen KB, Traynelis SF. Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci. 2011 Mar 9;31(10):3650-61. doi: 10.1523/JNEUROSCI.5565-10.2011. PMID: 21389220; PMCID: PMC3063124.