UNC7700

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 126770

CAS#: N/A

Description: UNC7700 is an EED-binding PROTAC degrader with DC50 (EED) = 110 nM, and DC50 (EZH2) = 280 nM.

Chemical Structure

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UNC7700
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 126770
Name: UNC7700
CAS#: N/A
Chemical Formula: C44H48N10O6S
Exact Mass: 844.35
Molecular Weight: 844.992
Elemental Analysis: C, 62.54; H, 5.73; N, 16.58; O, 11.36; S, 3.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UNC7700; UNC-7700; UNC 7700

IUPAC/Chemical Name: (2S,4R)-1-((S)-2-((1s,3R)-3-(4-(5-((furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)cyclobutane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

InChi Key: ARONHQOAKYUHEE-AOBTXCIISA-N

InChi Code: InChI=1S/C44H48N10O6S/c1-25-36(61-24-48-25)28-9-7-26(8-10-28)19-45-41(58)35-18-32(55)22-53(35)42(59)37(44(2,3)4)51-40(57)30-16-31(17-30)50-39(56)29-13-11-27(12-14-29)34-21-47-43(54-23-49-52-38(34)54)46-20-33-6-5-15-60-33/h5-15,21,23-24,30-32,35,37,55H,16-20,22H2,1-4H3,(H,45,58)(H,46,47)(H,50,56)(H,51,57)/t30-,31+,32-,35+,37-/m1/s1

SMILES Code: O=C(N[C@H]1C[C@@H](C(N[C@@H](C(C)(C)C)C(N2C[C@H](O)C[C@H]2C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)=O)=O)C1)C5=CC=C(C6=CN=C(NCC7=CC=CO7)N8C6=NN=C8)C=C5

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 844.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Bashore FM, Foley CA, Ong HW, Rectenwald JM, Hanley RP, Norris-Drouin JL, Cholensky SH, Mills CA, Pearce KH, Herring LE, Kireev D, Frye SV, James LI. PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS Chem Biol. 2023 Mar 17;18(3):494-507. doi: 10.1021/acschembio.2c00804. Epub 2023 Mar 6. PMID: 36877831; PMCID: PMC10023369.