ZX703

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 126325

CAS#: N/A

Description: ZX703 is a GPX4 degrader which induces Ferroptosis in Human Cancer Cells (DC50 = 0.135 uM in HT1080). ZX703 significantly degraded GPX4 through the ubiquitin−proteasome and the autophagy−lysosome pathways in a dose- and time-dependent manner. Moreover, ZX703 was found to induce the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells, thereby inducing ferroptosis.

Chemical Structure

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ZX703
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 126325
Name: ZX703
CAS#: N/A
Chemical Formula: C54H67ClN8O9S
Exact Mass: 1,038.44
Molecular Weight: 1,039.687
Elemental Analysis: C, 62.38; H, 6.50; Cl, 3.41; N, 10.78; O, 13.85; S, 3.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ZX703; ZX 703; ZX-703

IUPAC/Chemical Name: (2S)-1-((2S)-2-(10-(4-((4-chlorophenyl)(4-(5-methyl-4-nitroisoxazole-3-carbonyl)piperazin-1-yl)methyl)phenoxy)decanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

InChi Key: UGSZNMDKYDYBGA-HFYPCKMSSA-N

InChi Code: InChI=1S/C54H67ClN8O9S/c1-35-49(73-34-57-35)40-16-14-37(15-17-40)32-56-51(66)44-31-42(64)33-62(44)53(68)50(54(3,4)5)58-45(65)13-11-9-7-6-8-10-12-30-71-43-24-20-39(21-25-43)48(38-18-22-41(55)23-19-38)60-26-28-61(29-27-60)52(67)46-47(63(69)70)36(2)72-59-46/h14-25,34,42,44,48,50,64H,6-13,26-33H2,1-5H3,(H,56,66)(H,58,65)/t42?,44-,48?,50+/m0/s1

SMILES Code: CC1=C([N+]([O-])=O)C(C(N2CCN(C(C3=CC=C(OCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4CC(O)C[C@H]4C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)C=C3)C7=CC=C(Cl)C=C7)CC2)=O)=NO1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,039.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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ZX703: A Small-Molecule Degrader of GPX4 Inducing Ferroptosis in Human Cancer Cells
Mengdie Hu, Xiaomei Li, Lin Wang, Yanping Zhang, Yujie Sun, Hui Hua, Huina Liu, Ting Cai, Dongsheng Zhu, and Qiuping Xiang
ACS Medicinal Chemistry Letters Article ASAP
DOI: 10.1021/acsmedchemlett.3c00571