HG-106
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MedKoo CAT#: 124082

CAS#: 928712-10-1

Description: HG-106 is a potent SLC7A11 inhibitor. HG-106 markedly decreased cystine uptake and intracellular glutathione biosynthesis. Furthermore, HG106 exhibited selective cytotoxicity toward KRAS-mutant cells by increasing oxidative stress- and ER stress-mediated cell apoptosis. Of note, treatment of KRAS-mutant LUAD with HG-106 in several preclinical lung cancer mouse models led to marked tumor suppression and prolonged survival.

Chemical Structure

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HG-106
CAS# 928712-10-1
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 124082
Name: HG-106
CAS#: 928712-10-1
Chemical Formula: C15H13ClN4O2
Exact Mass: 316.07
Molecular Weight: 316.750
Elemental Analysis: C, 56.88; H, 4.14; Cl, 11.19; N, 17.69; O, 10.10

Price and Availability

Size Price Availability Quantity
5mg USD 90 Ready to ship
10mg USD 150 Ready to ship
25mg USD 250 Ready to ship
50mg USD 450 Ready to ship
100mg USD 750 Ready to ship
200mg USD 1350 Ready to ship
Bulk inquiry

Synonym: HG106; HG-106; HG 106; EX-A7255; EN300-27696107; Z3219837442

IUPAC/Chemical Name: 2-chloro-N-[2-(4-methoxyphenyl)benzotriazol-5-yl]acetamide

InChi Key: YKONCCSKKBLMDS-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H13ClN4O2/c1-22-12-5-3-11(4-6-12)20-18-13-7-2-10(8-14(13)19-20)17-15(21)9-16/h2-8H,9H2,1H3,(H,17,21)

SMILES Code: O=C(NC1=CC2=NN(C3=CC=C(OC)C=C3)N=C2C=C1)CCl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: HG-106 is a potent SLC7A11 inhibitor.
In vitro activity: To be determined
In vivo activity: Treatment of KRAS-mutant lung adenocarcinoma (LUAD) with HG-106 in several preclinical lung cancer mouse models led to marked tumor suppression and prolonged survival. HG-106 markedly decreased cystine uptake and intracellular glutathione biosynthesis. HG-106 exhibited selective cytotoxicity toward KRAS-mutant cells by increasing oxidative stress- and ER stress-mediated cell apoptosis. Reference: J Clin Invest. 2020 Apr 1;130(4):1752-1766. https://pubmed.ncbi.nlm.nih.gov/31874110/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 125.0 394.65

Preparing Stock Solutions

The following data is based on the product molecular weight 316.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Hu K, Li K, Lv J, Feng J, Chen J, Wu H, Cheng F, Jiang W, Wang J, Pei H, Chiao PJ, Cai Z, Chen Y, Liu M, Pang X. Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma. J Clin Invest. 2020 Apr 1;130(4):1752-1766. doi: 10.1172/JCI124049. PMID: 31874110; PMCID: PMC7108883.
In vitro protocol: To be determined
In vivo protocol: 1. Hu K, Li K, Lv J, Feng J, Chen J, Wu H, Cheng F, Jiang W, Wang J, Pei H, Chiao PJ, Cai Z, Chen Y, Liu M, Pang X. Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma. J Clin Invest. 2020 Apr 1;130(4):1752-1766. doi: 10.1172/JCI124049. PMID: 31874110; PMCID: PMC7108883.

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Hu K, Li K, Lv J, Feng J, Chen J, Wu H, Cheng F, Jiang W, Wang J, Pei H, Chiao PJ, Cai Z, Chen Y, Liu M, Pang X. Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma. J Clin Invest. 2020 Apr 1;130(4):1752-1766. doi: 10.1172/JCI124049. PMID: 31874110; PMCID: PMC7108883.