SLU-10482

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 123938

CAS#: N/A

Description: SLU-10482 is an agent potentially useful for treatment of cryptosporidiosis. SLU-10482 has EC50 = 0.07 μΜ, which was found to be orally efficacious with an ED90 < 5 mg/kg BID in a Cryptosporidiuminfection mouse model, superior to SLU-2633.

Chemical Structure

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SLU-10482
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 123938
Name: SLU-10482
CAS#: N/A
Chemical Formula: C18H16F4N6O
Exact Mass: 408.13
Molecular Weight: 408.360
Elemental Analysis: C, 52.94; H, 3.95; F, 18.61; N, 20.58; O, 3.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SLU-10482; SLU10482; SLU 10482

IUPAC/Chemical Name: 1-(4-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperazin-1-yl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one

InChi Key: NIBRKSRYSFJILK-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16F4N6O/c19-14-2-1-12(9-13(14)18(20,21)22)10-17(29)27-7-5-26(6-8-27)16-4-3-15-24-23-11-28(15)25-16/h1-4,9,11H,5-8,10H2

SMILES Code: O=C(N1CCN(C2=NN3C(C=C2)=NN=C3)CC1)CC4=CC=C(F)C(C(F)(F)F)=C4

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 408.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Schubert TJ, Oboh E, Peek H, Philo E, Teixeira JE, Stebbins EE, Miller P, Oliva J, Sverdrup FM, Griggs DW, Huston CD, Meyers MJ. Structure-Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Cryptosporidium Reveals Remarkable Role of Fluorine. J Med Chem. 2023 Jun 2. doi: 10.1021/acs.jmedchem.3c00110. Epub ahead of print. PMID: 37267631.