SHP2 inhibitor CNBDA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130526

CAS#: 2101321-90-6

Description: SHP2 inhibitor CNBDA is a novel SHP2 inhibitor (IC50 of 5 μM). SHP2 inhibitor CNBDA has promising anti-breast cancer cell effects.

Chemical Structure

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SHP2 inhibitor CNBDA
CAS# 2101321-90-6
Instruction

Theoretical Analysis

MedKoo Cat#: 130526
Name: SHP2 inhibitor CNBDA
CAS#: 2101321-90-6
Chemical Formula: C30H40O7
Exact Mass: 512.28
Molecular Weight: 512.640
Elemental Analysis: C, 70.29; H, 7.87; O, 21.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CNBDA, SHP2 In CNBDA, SHP2-In-CNBDA

IUPAC/Chemical Name: 4,4'-(4'-Carboxy-4-(nonyloxy)-[1,1'-biphenyl]-3,5-diyl)dibutyric acid

InChi Key: GLVGBEAYRNBVMW-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H40O7/c1-2-3-4-5-6-7-8-19-37-29-24(11-9-13-27(31)32)20-26(21-25(29)12-10-14-28(33)34)22-15-17-23(18-16-22)30(35)36/h15-18,20-21H,2-14,19H2,1H3,(H,31,32)(H,33,34)(H,35,36)

SMILES Code: CCCCCCCCCOC1=C(CCCC(O)=O)C=C(C2=CC=C(C(O)=O)C=C2)C=C1CCCC(O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 512.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Lade DM, Nicoletti R, Mersch J, Agazie YM. Design and synthesis of improved active-site SHP2 inhibitors with anti-breast cancer cell effects. Eur J Med Chem. 2023 Feb 5;247:115017. doi: 10.1016/j.ejmech.2022.115017. Epub 2022 Dec 12. PMID: 36584630.

2. Hartman Z, Geldenhuys WJ, Agazie YM. Novel Small-Molecule Inhibitor for the Oncogenic Tyrosine Phosphatase SHP2 with Anti-Breast Cancer Cell Effects. ACS Omega. 2020 Sep 25;5(39):25113-25124. doi: 10.1021/acsomega.0c02746. PMID: 33043190; PMCID: PMC7542598.