SLB1122168 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 123111

CAS#: N/A

Description: SLB1122168 is a potent inhibitor (IC50 = 94 ± 6 nM) of Spns2-mediated S1P release. Administration of SLB1122168 to mice and rats resulted in a dose dependent decrease in circulating lymphocytes, a pharmacodynamic indication of Spns2 inhibition. SLB1122168 provides a valuable tool compound to explore both the therapeutic potential of targeting Spns2 and the physiologic consequences of selective S1P export inhibition.

Chemical Structure

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SLB1122168 HCl
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 123111
Name: SLB1122168 HCl
CAS#: N/A
Chemical Formula: C22H36ClN3O
Exact Mass: 393.25
Molecular Weight: 394.000
Elemental Analysis: C, 67.07; H, 9.21; Cl, 9.00; N, 10.67; O, 4.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SLB1122168; SLB-1122168; SLB 1122168

IUPAC/Chemical Name: (S)-6-decyl-N-(pyrrolidin-3-ylmethyl)benzo[d]oxazol-2-amine hydrochloride

InChi Key: VVHUHNZYNZOTEH-FYZYNONXSA-N

InChi Code: InChI=1S/C22H35N3O.ClH/c1-2-3-4-5-6-7-8-9-10-18-11-12-20-21(15-18)26-22(25-20)24-17-19-13-14-23-16-19;/h11-12,15,19,23H,2-10,13-14,16-17H2,1H3,(H,24,25);1H/t19-;/m0./s1

SMILES Code: CCCCCCCCCCC1=CC=C2N=C(NC[C@@H]3CNCC3)OC2=C1.[H]Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 394.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Burgio AL, Shrader CW, Kharel Y, Huang T, Salamoun JM, Lynch KR, Santos WL. 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). J Med Chem. 2023 Apr 3. doi: 10.1021/acs.jmedchem.3c00149. Epub ahead of print. PMID: 37010497.