SRI-32743

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130240

CAS#: N/A

Description: SRI-32743 is an allosteric modulator of DAT.

Chemical Structure

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SRI-32743
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 130240
Name: SRI-32743
CAS#: N/A
Chemical Formula: C26H25N5
Exact Mass: 407.21
Molecular Weight: 407.520
Elemental Analysis: C, 76.63; H, 6.18; N, 17.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SRI-32743; SRI32743; SRI 32743

IUPAC/Chemical Name: 2-(7-methylimidazo[1,2-a]pyridin-6-yl)-N-(2-phenylbutyl)quinazolin-4-amine

InChi Key: UDWNMXJUXZMYHO-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H25N5/c1-3-19(20-9-5-4-6-10-20)16-28-25-21-11-7-8-12-23(21)29-26(30-25)22-17-31-14-13-27-24(31)15-18(22)2/h4-15,17,19H,3,16H2,1-2H3,(H,28,29,30)

SMILES Code: CCC(C1=CC=CC=C1)CNC2=NC(C(C(C)=C3)=CN4C3=NC=C4)=NC5=C2C=CC=C5

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 407.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Zhu J, Quizon PM, Wang Y, Adeniran CA, Strauss MJ, Jiménez-Torres AC, Patel P, Cirino TJ, Eans SO, Hammond HR, Deliscar LS, O'Hara P, Saini SK, Ofori E, Vekariya RH, Zhang S, Moukha-Chafiq O, Nguyen TH, Ananthan S, Augelli-Szafran CE, Zhan CG, McLaughlin JP. SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice. Neuropharmacology. 2022 Dec 1;220:109239. doi: 10.1016/j.neuropharm.2022.109239. Epub 2022 Sep 17. PMID: 36126727.

2. Davis SE, Ferris MJ, Ananthan S, Augelli-Szafran CE, Zhu J. Novel Allosteric Modulator Southern Research Institute-32743 Reverses HIV-1 Transactivator of Transcription-Induced Increase in Dopamine Release in the Caudate Putamen of Inducible Transactivator of Transcription Transgenic Mice. J Pharmacol Exp Ther. 2023 Feb;384(2):306-314. doi: 10.1124/jpet.122.001291. Epub 2022 Dec 1. PMID: 36456195; PMCID: PMC9875314.