SHC014748M

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130220

CAS#: N/A

Description: SHC014748M is a PI3Kδ inhibitor that was proposed as a potential treatment for non-Hodgkin lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma. In an in vivo study in mice, SHC014748M was found to be highly selective and led to significant reduction in lymphoma cell growth. Furthermore, SHC014748M has undergone phase 1 and 2 clinical trials.

Chemical Structure

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SHC014748M
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 130220
Name: SHC014748M
CAS#: N/A
Chemical Formula: C23H21ClN6O4S
Exact Mass: 512.10
Molecular Weight: 512.970
Elemental Analysis: C, 53.85; H, 4.13; Cl, 6.91; N, 16.38; O, 12.48; S, 6.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SHC014748M; SHC 014748M

IUPAC/Chemical Name: (S)-4-amino-6-((1-(8-chloro-4-oxo-2-phenyl-1,4-dihydroquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile methanesulfonate

InChi Key: GUZPLFWFFSZBIA-YDALLXLXSA-N

InChi Code: InChI=1S/C22H17ClN6O.CH4O3S/c1-12(28-22-15(10-24)21(25)26-11-27-22)17-18(13-6-3-2-4-7-13)29-19-14(20(17)30)8-5-9-16(19)23;1-5(2,3)4/h2-9,11-12H,1H3,(H,29,30)(H3,25,26,27,28);1H3,(H,2,3,4)/t12-;/m0./s1

SMILES Code: N#CC1=C(N[C@H](C2=C(C3=CC=CC=C3)NC4=C(C=CC=C4Cl)C2=O)C)N=CN=C1N.OS(=O)(C)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 512.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. https://clinicaltrials.gov/ct2/show/results/NCT04431089

2. Fan L, Wang C, Zhao L, Wang Z, Zhang X, Liu X, Cao L, Xu W, Li J. SHC014748M, a novel selective inhi-bitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B cell lymphomas and chronic lymphocytic leukemia. Neoplasia. 2020 Dec;22(12):714-724. doi: 10.1016/j.neo.2020.10.004. Epub 2020 Oct 23. PMID: 33142237; PMCID: PMC7586065.

3. Guo F, Liu B, Li X, Wang H, Zhu X, Su Y, He C, Zhu M, Ding J, Xu Y, Zhao X, Wang Y, Shan R, Zhu J, Xie J, Ge Q, Fan L, Ding Y, Xie Y, Zhang C, Li H, Wang H, Zhou H. Mass balance, metabolic disposition, and pharmacokinetics of a novel selective inhibitor of PI3Kδ [14C] SHC014748M in healthy Chinese subjects following oral administration. Cancer Chemother Pharmacol. 2023 Feb;91(2):143-156. doi: 10.1007/s00280-022-04493-5. Epub 2022 Dec 27. PMID: 36572783.