AG-690/11026014

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130076

CAS#: N/A

Description: AG-690/11026014 is a PARP-1 inhibitor that has been shown to prevent Ang II-induced cardiomyocyte hypertrophy in mice and therefore, has potential to treat cardiac diseases.

Chemical Structure

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AG-690/11026014
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 130076
Name: AG-690/11026014
CAS#: N/A
Chemical Formula: C17H19Cl2N5O4S
Exact Mass: 459.05
Molecular Weight: 460.330
Elemental Analysis: C, 44.36; H, 4.16; Cl, 15.40; N, 15.21; O, 13.90; S, 6.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AG-690/11026014; AG 690/11026014; AG690/11026014

IUPAC/Chemical Name: 2-((7-(3-(4-Chlorophenoxy)propyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)thio)acetamide hydrochloride

InChi Key: UDICOWCXHICWSU-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18ClN5O4S.ClH/c1-22-14-13(15(25)21-16(22)26)23(17(20-14)28-9-12(19)24)7-2-8-27-11-5-3-10(18)4-6-11;/h3-6H,2,7-9H2,1H3,(H2,19,24)(H,21,25,26);1H

SMILES Code: O=C(N)CSC(N1CCCOC2=CC=C(Cl)C=C2)=NC(N(C)C(N3)=O)=C1C3=O.[H]Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 460.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Liu M, Li Z, Chen GW, Li ZM, Wang LP, Ye JT, Luo HB, Liu PQ. AG-690/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy. Mol Cell Endocrinol. 2014 Jul 5;392(1-2):14-22. doi: 10.1016/j.mce.2014.05.010. Epub 2014 May 21. PMID: 24859603.

2. Feng GS, Zhu CG, Li ZM, Wang PX, Huang Y, Liu M, He P, Lou LL, Chen SR, Liu PQ. Synthesis of the novel PARP-1 inhibitor AG-690/11026014 and its protective effects on angiotensin II-induced mouse cardiac remodeling. Acta Pharmacol Sin. 2017 May;38(5):638-650. doi: 10.1038/aps.2016.159. Epub 2017 Feb 27. PMID: 28239158; PMCID: PMC5457692.