(S, R, S)-AHPC-PEG6-acid
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MedKoo CAT#: 122167

CAS#: N/A

Description: (S, R, S)-AHPC-PEG6-acid is a synthetic PROTAC linker that incorporates an E3 ligase ligand with a PEG6 arm to empower PROTAC drug research & discovery. It is reactive with amine containing molecule. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media.

Chemical Structure

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(S, R, S)-AHPC-PEG6-acid
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 122167
Name: (S, R, S)-AHPC-PEG6-acid
CAS#: N/A
Chemical Formula: C38H58N4O12S
Exact Mass: 794.38
Molecular Weight: 794.960
Elemental Analysis: C, 57.41; H, 7.35; N, 7.05; O, 24.15; S, 4.03

Price and Availability

Size Price Availability Quantity
100mg USD 850 2 Weeks
250mg USD 1450 2 Weeks
500mg USD 2450 2 Weeks
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Synonym: (S, R, S)-AHPC-PEG6-acid

IUPAC/Chemical Name: (S)-24-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-25,25-dimethyl-22-oxo-4,7,10,13,16,19-hexaoxa-23-azahexacosanoic acid

InChi Key: QMXRCLRQNTZWDA-WTLBPJHYSA-N

InChi Code: InChI=1S/C38H58N4O12S/c1-27-34(55-26-40-27)29-7-5-28(6-8-29)24-39-36(47)31-23-30(43)25-42(31)37(48)35(38(2,3)4)41-32(44)9-11-49-13-15-51-17-19-53-21-22-54-20-18-52-16-14-50-12-10-33(45)46/h5-8,26,30-31,35,43H,9-25H2,1-4H3,(H,39,47)(H,41,44)(H,45,46)/t30-,31+,35-/m1/s1

SMILES Code: CC(C)(C)[C@@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)NC(CCOCCOCCOCCOCCOCCOCCC(O)=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 794.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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