ARN70080
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 121166

CAS#: 2417370-08-0

Description: ARN70080 is a ProTAC building block. ARN70080 contains a von Hippel--Lindau (VHL)-rectuiting ligand and a pendant disulfide, linked via a carbonate group. The pendant disulfide allows for targeted degradation of antibodies. This product has no formal name at the moment. For the convenience of communication, a temporal code was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

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ARN70080
CAS# 2417370-08-0
Instruction

Theoretical Analysis

MedKoo Cat#: 121166
Name: ARN70080
CAS#: 2417370-08-0
Chemical Formula: C33H48N4O9S3
Exact Mass: 740.26
Molecular Weight: 740.950
Elemental Analysis: C, 53.49; H, 6.53; N, 7.56; O, 19.43; S, 12.98

Price and Availability

Size Price Availability Quantity
50mg USD 705 2 Weeks
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Synonym: (S,R,S)-AHPC-di-trimethylamide-dioxodisulfide-carbonate ester

IUPAC/Chemical Name: S-(1-(((((3R,5S)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)-2-methylpropan-2-yl) methanesulfonothioate

InChi Key: AZAVKYSXGOPVNY-RMTZWNOUSA-N

InChi Code: InChI=1S/C33H48N4O9S3/c1-20-25(47-19-35-20)22-13-11-21(12-14-22)16-34-27(38)24-15-23(45-30(41)44-18-33(8,9)48-49(10,42)43)17-37(24)28(39)26(31(2,3)4)36-29(40)46-32(5,6)7/h11-14,19,23-24,26H,15-18H2,1-10H3,(H,34,38)(H,36,40)/t23-,24+,26-/m1/s1

SMILES Code: CS(=O)(SC(C)(C)COC(O[C@H]1CN(C([C@@H](NC(OC(C)(C)C)=O)C(C)(C)C)=O)[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C1)=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 740.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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