IRAK inhibitor 3

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208253

CAS#: 1012343-93-9

Description: IRAK Inhibitor Protects the Intestinal Tract of Necrotizing Enterocolitis by Inhibiting the Toll-Like Receptor (TLR) Inflammatory Signaling Pathway in Rats

Chemical Structure

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IRAK inhibitor 3
CAS# 1012343-93-9
Instruction

Theoretical Analysis

MedKoo Cat#: 208253
Name: IRAK inhibitor 3
CAS#: 1012343-93-9
Chemical Formula: C21H21N5O4S
Exact Mass: 439.13
Molecular Weight: 439.490
Elemental Analysis: C, 57.39; H, 4.82; N, 15.94; O, 14.56; S, 7.29

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: IRAKinhibitor 3, IRAK-inhibitor 3, IRAK-inhibitor-3

IUPAC/Chemical Name: 4-(((3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)methyl)benzenesulfonamide

InChi Key: UPFVAHVWLNBVSG-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H21N5O4S/c1-29-18-8-5-15(11-19(18)30-2)17-13-24-21-10-9-20(25-26(17)21)23-12-14-3-6-16(7-4-14)31(22,27)28/h3-11,13H,12H2,1-2H3,(H,23,25)(H2,22,27,28)

SMILES Code: O=S(C1=CC=C(CNC2=NN3C(C=C2)=NC=C3C4=CC=C(OC)C(OC)=C4)C=C1)(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 439.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Futosi K, Fodor S, Mócsai A. Neutrophil cell surface receptors and their intracellular signal transduction pathways. Int Immunopharmacol. 2013 Nov;17(3):638-50. doi: 10.1016/j.intimp.2013.06.034. Epub 2013 Aug 30. PMID: 23994464; PMCID: PMC3827506.

2: Papathanasiou I, Trachana V, Mourmoura E, Tsezou A. DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis. Life Sci. 2019 Jul 1;228:274-284. doi: 10.1016/j.lfs.2019.05.018. Epub 2019 May 9. PMID: 31077718.

3: Hou Y, Lu X, Zhang Y. IRAK Inhibitor Protects the Intestinal Tract of Necrotizing Enterocolitis by Inhibiting the Toll-Like Receptor (TLR) Inflammatory Signaling Pathway in Rats. Med Sci Monit. 2018 May 22;24:3366-3373. doi: 10.12659/MSM.910327. PMID: 29784900; PMCID: PMC5992962.

4: Geng D, Ciavattone N, Lasola JJ, Shrestha R, Sanchez A, Guo J, Vlk A, Younis R, Wang L, Brown AJ, Zhang Y, Velasco-Gonzalez C, Tan AC, Davila E. Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. Commun Biol. 2020 Jun 12;3(1):306. doi: 10.1038/s42003-020-1033-y. PMID: 32533049; PMCID: PMC7293221.

5: Wang Z, Wesche H, Stevens T, Walker N, Yeh WC. IRAK-4 inhibitors for inflammation. Curr Top Med Chem. 2009;9(8):724-37. doi: 10.2174/156802609789044407. PMID: 19689377; PMCID: PMC3182414.

6: Hulsmans M, Geeraert B, De Keyzer D, Mertens A, Lannoo M, Vanaudenaerde B, Hoylaerts M, Benhabilès N, Tsatsanis C, Mathieu C, Holvoet P. Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome. PLoS One. 2012;7(1):e30414. doi: 10.1371/journal.pone.0030414. Epub 2012 Jan 17. PMID: 22272346; PMCID: PMC3260289.

7: Antosz H, Choroszyńska D. Negatywna regulacja sygnalizacji receptorów Toll- podobnych [Negative regulation of Toll-like receptor signalling]. Postepy Hig Med Dosw (Online). 2013 Apr 25;67:339-50. Polish. doi: 10.5604/17322693.1046538. PMID: 23619234.

8: Kirou KA, Gkrouzman E. Anti-interferon alpha treatment in SLE. Clin Immunol. 2013 Sep;148(3):303-12. doi: 10.1016/j.clim.2013.02.013. Epub 2013 Mar 1. PMID: 23566912.

9: Rahemi S, Nematollahi-Mahani SN, Rajaie A, Fallah H. Inhibitor of Interleukin-1 Receptor-associated Kinases 1/4, Can Increase the Sensitivity of Breast Cancer Cells to Methotrexate. Int J Mol Cell Med. 2019 Summer;8(3):200-209. doi: 10.22088/IJMCM.BUMS.8.3.200. PMID: 32489949; PMCID: PMC7241845.

10: Park JH, Lee JH, An JH, Park CW, Choi YP, Seo SW, Lee HW, Youn HY. Anticancer activity of IRAK-4 inhibitors against canine lymphoid malignancies. Vet Comp Oncol. 2022 Sep;20(3):632-640. doi: 10.1111/vco.12816. Epub 2022 May 18. PMID: 35340094.