FPFT-2216

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208145

CAS#: 2367619-87-0

Description: FPFT-2216, a previously reported "molecular glue" compound, degrades PDE6D, in addition to IKZF1, IKZF3, and CK1α

Chemical Structure

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FPFT-2216
CAS# 2367619-87-0
Instruction

Theoretical Analysis

MedKoo Cat#: 208145
Name: FPFT-2216
CAS#: 2367619-87-0
Chemical Formula: C12H12N4O3S
Exact Mass: 292.06
Molecular Weight: 292.310
Elemental Analysis: C, 49.31; H, 4.14; N, 19.17; O, 16.42; S, 10.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: FP-FT-2216, FPFT2216, FPFT 2216, FPFT-22-16, FP-FT-22-16

IUPAC/Chemical Name: 3-(4-(4-Methoxythiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidine-2,6-dione

InChi Key: SKUSCUALKIOIST-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H12N4O3S/c1-19-10-6-20-5-7(10)8-4-16(15-14-8)9-2-3-11(17)13-12(9)18/h4-6,9H,2-3H2,1H3,(H,13,17,18)

SMILES Code: O=C(C(N1N=NC(C2=CSC=C2OC)=C1)CC3)NC3=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 292.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Teng M, Lu W, Donovan KA, Sun J, Krupnick NM, Nowak RP, Li YD, Sperling AS, Zhang T, Ebert BL, Fischer ES, Gray NS. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756. doi: 10.1021/acs.jmedchem.1c01832. Epub 2021 Dec 29. PMID: 34965125.


2: Gemechu Y, Millrine D, Hashimoto S, Prakash J, Sanchenkova K, Metwally H, Gyanu P, Kang S, Kishimoto T. Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11802-11807. doi: 10.1073/pnas.1814446115. Epub 2018 Oct 29. PMID: 30373817; PMCID: PMC6243262.