Carboxyphosphamide
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MedKoo CAT#: 112081

CAS#: 22788-18-7

Description: Carboxyphosphamide is an inactive metabolite of the alkylating agent cyclophosphamide.

Chemical Structure

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Carboxyphosphamide
CAS# 22788-18-7
Instruction

Theoretical Analysis

MedKoo Cat#: 112081
Name: Carboxyphosphamide
CAS#: 22788-18-7
Chemical Formula: C7H15Cl2N2O4P
Exact Mass: 292.01
Molecular Weight: 293.080
Elemental Analysis: C, 28.69; H, 5.16; Cl, 24.19; N, 9.56; O, 21.84; P, 10.57

Price and Availability

Size Price Availability Quantity
1mg USD 240 2 Weeks
5mg USD 570 2 Weeks
10mg USD 910 2 Weeks
25mg USD 1510 2 Weeks
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Synonym: Carboxyphosphamide; CPCOOH; NSC 145124; NSC145124; NSC-145124

IUPAC/Chemical Name: 3-((amino(bis(2-chloroethyl)amino)phosphoryl)oxy)propanoic acid

InChi Key: QLAKAJLYYGOZQL-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(10,14)15-6-1-7(12)13/h1-6H2,(H2,10,14)(H,12,13)

SMILES Code: O=C(O)CCOP(N)(N(CCCl)CCCl)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 293.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ludeman SM, Ho CK, Boal JH, Sweet EM, Chang YH. Carboxyphosphamide: NMR studies of its stability and cell membrane permeability. Drug Metab Dispos. 1992 Mar-Apr;20(2):337-8. PMID: 1352232.


2: Domeyer BE, Sladek NE. Inhibition by cyanamide of 4-hydroxycyclophosphamide/aldophosphamide oxidation to carboxyphosphamide. Biochem Pharmacol. 1981 Aug 1;30(15):2065-73. doi: 10.1016/0006-2952(81)90224-0. PMID: 7295327.


3: Manthey CL, Sladek NE. Kinetic characterization of the catalysis of "activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases. Biochem Pharmacol. 1988 Jul 15;37(14):2781-90. doi: 10.1016/0006-2952(88)90041-x. PMID: 3395357.


4: Hadidi AH, Coulter CE, Idle JR. Phenotypically deficient urinary elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients. Cancer Res. 1988 Sep 15;48(18):5167-71. PMID: 3409242.