Corydine | CAS#476-69-7 | Inhibitor

Corydine
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 112050

CAS#: 476-69-7

Description: Corydine is an aporphine alkaloid and inhibits the proliferation of murine L1210 lymphocytic leukemia, B16/F10 melanoma, and P388 leukemia cells when used at concentrations ranging from 10 to 100 µg/ml.

Chemical Structure

Corydine

CAS# 476-69-7

Instruction

Theoretical Analysis

MedKoo Cat#: 112050
Name: Corydine
CAS#: 476-69-7
Chemical Formula: C20H23NO4
Exact Mass: 341.16
Molecular Weight: 341.410
Elemental Analysis: C, 70.36; H, 6.79; N, 4.10; O, 18.74

Price and Availability

Size	Price	Availability
1mg	USD 309	2 Weeks
5mg	USD 900	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: (+)-Corydine; (+)Corydine; (+) Corydine; Corydine

IUPAC/Chemical Name: (S)-2,10,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

InChi Key: IDQUPXZJURZAGF-ZDUSSCGKSA-N

InChi Code: InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)19(22)18-16(12)13(21)9-11-5-6-14(23-2)20(25-4)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1

SMILES Code: OC1=C2C3=C(CCN([C@]3(CC4=CC=C(C(OC)=C42)OC)[H])C)C=C1OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 341.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Shafiee A, Jafarabadi AH. Corydine and norcorydine from the roots of Chelidonium majus. Planta Med. 1998 Jun;64(5):489. doi: 10.1055/s-2006-957498. PMID: 17253273.

2: Kaserer T, Steinacher T, Kainhofer R, Erli F, Sturm S, Waltenberger B, Schuster D, Spetea M. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10(1):13804. doi: 10.1038/s41598-020-70493-1. PMID: 32796875; PMCID: PMC7427800.

3: Kondo Y, Imai Y, Hojo H, Endo T, Nozoe S. Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine. J Pharmacobiodyn. 1990 Jul;13(7):426-31. doi: 10.1248/bpb1978.13.426. PMID: 2290126.

4: Gerecke M, Borer R, Brossi A. Selective ther cleavage in the aporphine series. Conversion of (S)-bulbocapnine into (S)-corytuberine and (S)-corydine methyl ether. Helv Chim Acta. 1976 Nov 3;59(7):2551-7. doi: 10.1002/hlca.19760590731. PMID: 14090.

5: Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L. Alkaloids of Corydalis slivenensis. Planta Med. 1982 Mar;44(3):168-70. doi: 10.1055/s-2007-971432. PMID: 17402105.

6: Debray M, Plat M, Le Men J. Alcaloïdes des Ménispermacées africaines. II. Stephania dinklagei (Engl.) Diels: isolement de la (plus) corydine, de la (plus) isocorydine et de la (minus) roemérine [Alkaloids of African Menispermaceae. II. Stephania dinklagei (Engl.) Diels: isolation of (plus) corydine, (plus) isocorydine and (minus) roemerine]. Ann Pharm Fr. 1967 Mar;25(3):237-42. French. PMID: 5611531.

7: Parvin MS, Chlebek J, Hošťálková A, Catapano MC, Lomozová Z, Macáková K, Mladěnka P. Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper. Molecules. 2022 Sep 29;27(19):6429. doi: 10.3390/molecules27196429. PMID: 36234964; PMCID: PMC9572997.

8: Ablajan N, Zhao B, Wenjuan X, Zhao J, Sagdullaev SS, Guoan Z, Aisa HA. Chemical components of Aconitum barbatum var. puberulum and their cytotoxic and antibacterial activities. Nat Prod Res. 2023 Apr;37(8):1382-1385. doi: 10.1080/14786419.2021.2005050. Epub 2021 Nov 22. PMID: 34802347.

9: Adsersen A, Kjølbye A, Dall O, Jäger AK. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort. J Ethnopharmacol. 2007 Aug 15;113(1):179-82. doi: 10.1016/j.jep.2007.05.006. Epub 2007 May 6. PMID: 17574358.

10: Kiryakov HG, Iskrenova E, Kuzmanov B, Evstatieva L. Alkaloids from Corydalis marschalliana. Planta Med. 1981 Mar;41(3):298-302. doi: 10.1055/s-2007-971718. PMID: 17401850.

11: Kiryakov HG, Iskrenova E, Kuzmanov B, Evstatieva L. Alkaloids from Corydalis bulbosa. Planta Med. 1981 Sep;43(1):51-5. doi: 10.1055/s-2007-971472. PMID: 17402008.

12: Hu R, Dai X, Lu Y, Pan Y. Preparative separation of isoquinoline alkaloids from Stephania yunnanensis by pH-zone-refining counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1881-4. doi: 10.1016/j.jchromb.2010.05.005. Epub 2010 May 9. PMID: 20570221.

13: Gören AC, Zhou BN, Kingston DG. Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei. Planta Med. 2003 Sep;69(9):867-8. doi: 10.1055/s-2003-43224. PMID: 14598219.

14: He SM, Song WL, Cong K, Wang X, Dong Y, Cai J, Zhang JJ, Zhang GH, Yang JL, Yang SC, Fan W. Identification of candidate genes involved in isoquinoline alkaloids biosynthesis in Dactylicapnos scandens by transcriptome analysis. Sci Rep. 2017 Aug 22;7(1):9119. doi: 10.1038/s41598-017-08672-w. PMID: 28831066; PMCID: PMC5567367.

15: Camacho MR, Kirby GC, Warhurst DC, Croft SL, Phillipson JD. Oxoaporphine alkaloids and quinones from Stephania dinklagei and evaluation of their antiprotozoal activities. Planta Med. 2000 Jun;66(5):478-80. doi: 10.1055/s-2000-8597. PMID: 10909274.

16: Husna Hasnan MH, Sivasothy Y, Khaw KY, Nafiah MA, Hazni H, Litaudon M, Wan Ruzali WA, Liew SY, Awang K. N-Methyl Costaricine and Costaricine, Two Potent Butyrylcholinesterase Inhibitors from Alseodaphne pendulifolia Gamb. Int J Mol Sci. 2023 Jun 27;24(13):10699. doi: 10.3390/ijms241310699. PMID: 37445877; PMCID: PMC10341795.

17: Dai X, Hu R, Sun C, Pan Y. Comprehensive separation and analysis of alkaloids from Stephania yunnanensis by counter-current chromatography coupled with liquid chromatography tandem mass spectrometry analysis. J Chromatogr A. 2012 Feb 24;1226:18-23. doi: 10.1016/j.chroma.2011.10.022. Epub 2011 Oct 14. PMID: 22041142.

18: Gözler T. Alkaloids of Turkish Glaucium species. Planta Med. 1982 Nov;46(3):179-80. doi: 10.1055/s-2007-971209. PMID: 17396968.

19: Chen Y, Li M, Liu J, Yan Q, Zhong M, Liu J, Di D, Liu J. Simultaneous determination of the content of isoquinoline alkaloids in Dicranostigma leptopodum (Maxim) Fedde and the effective fractionation of the alkaloids by high-performance liquid chromatography with diode array detection. J Sep Sci. 2015 Jan;38(1):9-17. doi: 10.1002/jssc.201400905. Epub 2014 Nov 19. PMID: 25330407.

20: Zhang M, Liang G, Yu J, Pan W. Aporphine alkaloids from the roots of Stephania viridiflavens. Nat Prod Res. 2010 Aug;24(13):1243-7. doi: 10.1080/14786410903125393. PMID: 20645211.

Your view history

Corydine featured