Z-505

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465822

CAS#: unknown

Description: Z-505 is a GHS-R1a ligand.

Chemical Structure

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Z-505
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465822
Name: Z-505
CAS#: unknown
Chemical Formula: C28H37N5O4S
Exact Mass: 539.26
Molecular Weight: 539.695
Elemental Analysis: C, 62.31; H, 6.91; N, 12.98; O, 11.86; S, 5.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Z-505; Z505; Z 505;

IUPAC/Chemical Name: (2R)-2-(2-amino-2-methylpropanamido)-4-methyl-N-(2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl)pentanamide

InChi Key: WTPBPKNYMZWUEV-VQCQRNETSA-N

InChi Code: InChI=1S/C28H37N5O4S/c1-17(2)13-20(31-27(37)28(3,4)29)25(35)30-21-14-19-7-5-8-22(32-11-6-9-23(32)34)24(19)33(26(21)36)15-18-10-12-38-16-18/h5,7-8,10,12,16-17,20-21H,6,9,11,13-15,29H2,1-4H3,(H,30,35)(H,31,37)/t20-,21?/m1/s1

SMILES Code: O=C(CCC1)N1C2=C(N(CC3=CSC=C3)C(C(NC([C@H](NC(C(C)(N)C)=O)CC(C)C)=O)C4)=O)C4=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 539.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shiomi Y, Yoshimura M, Hori Y, Ohira Y, Nagahama K, Ozaki T, Takei M, Tanaka T, Uno T. Z-505, an Oral Ghrelin Receptor Agonist, Attenuates Anorexia After Total Gastrectomy in Rats. J Surg Res. 2020 Feb;246:527-534. doi: 10.1016/j.jss.2019.09.035. Epub 2019 Oct 25. PMID: 31668932.

2: Shiomi Y, Ohira Y, Yoshimura M, Ozaki T, Takei M, Tanaka T. Z-505 hydrochloride ameliorates chemotherapy-induced anorexia in rodents via activation of the ghrelin receptor, GHSR1a. Eur J Pharmacol. 2018 Jan 5;818:148-157. doi: 10.1016/j.ejphar.2017.10.047. Epub 2017 Oct 21. PMID: 29066414.

3: Yoshimura M, Shiomi Y, Ohira Y, Takei M, Tanaka T. Z-505 hydrochloride, an orally active ghrelin agonist, attenuates the progression of cancer cachexia via anabolic hormones in Colon 26 tumor-bearing mice. Eur J Pharmacol. 2017 Sep 15;811:30-37. doi: 10.1016/j.ejphar.2017.05.036. Epub 2017 May 18. PMID: 28529141.