LY 165163
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414755

CAS#: 1814-64-8

Description: LY 165163 is a serotonin agonist.

Chemical Structure

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LY 165163
CAS# 1814-64-8
Instruction

Theoretical Analysis

MedKoo Cat#: 414755
Name: LY 165163
CAS#: 1814-64-8
Chemical Formula: C19H22F3N3
Exact Mass: 349.18
Molecular Weight: 349.400
Elemental Analysis: C, 65.31; H, 6.35; F, 16.31; N, 12.03

Price and Availability

Size Price Availability Quantity
25mg USD 285 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
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Synonym: LY 165163; LY165163; LY-165163; LY 165,163; LY165,163; LY-165,163.

IUPAC/Chemical Name: Benzenamine, 4-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-

InChi Key: GAAKALASJNGQKD-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2

SMILES Code: NC1=CC=C(CCN2CCN(C3=CC=CC(C(F)(F)F)=C3)CC2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 349.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fuller RW, Snoddy HD, Molloy BB. Central serotonin agonist actions of LY 165163, 1-(m-trifluoromethylphenyl)-4-(p-aminophenylethyl) piperazine, in rats. J Pharmacol Exp Ther. 1986 Nov;239(2):454-9. PMID: 2430093.

2: Hutson PH, Donohoe TP, Curzon G. Neurochemical and behavioural evidence for an agonist action of 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (LY 165163) at central 5-HT receptors. Eur J Pharmacol. 1987 Jun 19;138(2):215-23. doi: 10.1016/0014-2999(87)90435-3. PMID: 3113985.

3: Sprouse JS, Aghajanian GK. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse. 1987;1(1):3-9. doi: 10.1002/syn.890010103. PMID: 3505364.

4: Millan MJ, Rivet JM, Audinot V, Gobert A, Lejeune F, Brocco M, Newman- Tancredi A, Maurel-Remy S, Bervoets K. Antagonist properties of LY 165,163 at pre- and postsynaptic dopamine D2, D3 and D1 receptors: modulation of agonist actions at 5-HT1A receptors in vivo. J Pharmacol Exp Ther. 1995 Jun;273(3):1418-27. PMID: 7791116.

5: Sprouse JS, Aghajanian GK. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. 1988 Jul;27(7):707-15. doi: 10.1016/0028-3908(88)90079-2. PMID: 2901680.

6: Millan MJ, Bervoets K, Mavridis M. The serotonin (5-HT)1A agonist, LY 165,163, induces contralateral rotation in unilateral substantia nigra-lesioned rats via dopamine receptors. Neurosci Lett. 1991 Sep 16;130(2):173-6. doi: 10.1016/0304-3940(91)90390-f. PMID: 1795876.

7: Asarch KB, Ransom RW, Shih JC. 5-HT-1a and 5-HT-1b selectivity of two phenylpiperazine derivatives: evidence for 5-HT-1b heterogeneity. Life Sci. 1985 Apr 1;36(13):1265-73. doi: 10.1016/0024-3205(85)90271-1. PMID: 3982214.

8: Schoeffter P, Hoyer D. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br J Pharmacol. 1988 Nov;95(3):975-85. doi: 10.1111/j.1476-5381.1988.tb11728.x. PMID: 3207999; PMCID: PMC1854240.

9: Millan MJ, Rivet JM, Gobert A, Canton H, Veiga S, Bervoets K. 5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm. J Pharmacol Exp Ther. 1994 Apr;269(1):121-31. PMID: 7909555.

10: Takeuchi Y, Yang W, Shih JC. Identification of 5-hydroxytryptamine1A receptor proteins in bovine frontal cortex. J Neurochem. 1988 Nov;51(5):1343-9. doi: 10.1111/j.1471-4159.1988.tb01095.x. PMID: 3171582.