AZD5248

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465322

CAS#: 1254318-44-9

Description: AZD-5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1).

Chemical Structure

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AZD5248
CAS# 1254318-44-9
Instruction

Theoretical Analysis

MedKoo Cat#: 465322
Name: AZD5248
CAS#: 1254318-44-9
Chemical Formula: C22H22N4O2
Exact Mass: 374.17
Molecular Weight: 374.444
Elemental Analysis: C, 70.57; H, 5.92; N, 14.96; O, 8.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AZD5248; AZD 5248; AZD-5248;

IUPAC/Chemical Name: (S)-4-amino-N-(1-cyano-2-(4'-cyano-[1,1'-biphenyl]-4-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide

InChi Key: NNUFRZJZOXVZIT-FQEVSTJZSA-N

InChi Code: InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1

SMILES Code: NC1(C(N[C@H](C#N)CC2=CC=C(C3=CC=C(C#N)C=C3)C=C2)=O)CCOCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 374.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Banerjee A, Velagaleti R, Patil S, Pawar M, Yadav P, Kadam P, Qadri MM, Chakraborti S, Saini JS, Behera DB, Karanjai K, Iyer PS, Gharat LA, Das S. Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy. Bioorg Med Chem Lett. 2021 Sep 1;47:128202. doi: 10.1016/j.bmcl.2021.128202. Epub 2021 Jun 15. PMID: 34139325.

2: Kingston L, Gu C, Guo J, Swallow S, Elmore CS. The impact of radiochemistry in drug projects: The use of C-14 label in the AZD8529, AZD7325, and AZD6280 projects. J Labelled Comp Radiopharm. 2021 Feb;64(2):65-72. doi: 10.1002/jlcr.3902. Epub 2021 Jan 7. PMID: 33326121.

3: Allen P, Bragg RA, Caffrey M, Ericsson C, Hickey MJ, Kingston LP, Elmore CS. The synthesis of a tritium, carbon-14, and stable isotope-labeled cathepsin C inhibitors. J Labelled Comp Radiopharm. 2017 Feb;60(2):124-129. doi: 10.1002/jlcr.3483. Epub 2016 Dec 21. PMID: 27868229.

4: Bragg RA, Brocklehurst S, Gustafsson F, Goodman J, Hickling K, MacFaul PA, Swallow S, Tugwood J. Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation. Chem Res Toxicol. 2015 Oct 19;28(10):1991-9. doi: 10.1021/acs.chemrestox.5b00236. Epub 2015 Sep 16. PMID: 26351880.