MMV665917

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465269

CAS#: 904576-65-4

Description: MMV665917 is an anticryptosporidial agent with in vitro and in vivo efficacy against Cryptosporidium parvum. MMV665917 significantly reduced fecal oocyst excretion, parasite colonization and damage to the intestinal mucosa, and peak diarrheal symptoms, compared with infected untreated controls. MMV665917 appeared to be curative in a NOD SCID gamma mouse model of chronic cryptosporidiosis. MMV665917 was also efficacious in a gamma interferon knockout mouse model of acute cryptosporidiosis.

Chemical Structure

img
MMV665917
CAS# 904576-65-4
Instruction

Theoretical Analysis

MedKoo Cat#: 465269
Name: MMV665917
CAS#: 904576-65-4
Chemical Formula: C16H16ClN7O
Exact Mass: 357.11
Molecular Weight: 357.802
Elemental Analysis: C, 53.71; H, 4.51; Cl, 9.91; N, 27.40; O, 4.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MMV665917; MMV 665917; MMV-665917;

IUPAC/Chemical Name: 4-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-N-(4-chlorophenyl)piperazine-1-carboxamide

InChi Key: ZDXWENNHTOBFEW-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H16ClN7O/c17-12-1-3-13(4-2-12)19-16(25)23-9-7-22(8-10-23)15-6-5-14-20-18-11-24(14)21-15/h1-6,11H,7-10H2,(H,19,25)

SMILES Code: O=C(N1CCN(C2=NN3C(C=C2)=NN=C3)CC1)NC4=CC=C(Cl)C([H])=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Cryptosporidiosis, an enteric protozoon, causes substantial morbidity and mortality associated with diarrhea in children <2 years old in low- to middle-income countries. There is no vaccine and treatments are inadequate.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 357.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Oboh E, Schubert TJ, Teixeira JE, Stebbins EE, Miller P, Philo E, Thakellapalli H, Campbell SD, Griggs DW, Huston CD, Meyers MJ. Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin. J Med Chem. 2021 Aug 3. doi: 10.1021/acs.jmedchem.1c01136. Epub ahead of print. PMID: 34342443.

2: Love MS, Choy RKM. Emerging treatment options for cryptosporidiosis. Curr Opin Infect Dis. 2021 Jul 15. doi: 10.1097/QCO.0000000000000761. Epub ahead of print. PMID: 34261904.

3: Choy RKM, Huston CD. Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration. PLoS Negl Trop Dis. 2020 Jul 2;14(7):e0008252. doi: 10.1371/journal.pntd.0008252. PMID: 32614819; PMCID: PMC7332027.

4: Lee S, Ginese M, Girouard D, Beamer G, Huston CD, Osbourn D, Griggs DW, Tzipori S. Piperazine-Derivative MMV665917: An Effective Drug in the Diarrheic Piglet Model of Cryptosporidium hominis. J Infect Dis. 2019 Jun 19;220(2):285-293. doi: 10.1093/infdis/jiz105. PMID: 30893435; PMCID: PMC7368243.

5: Chavez MA, White AC Jr. Novel treatment strategies and drugs in development for cryptosporidiosis. Expert Rev Anti Infect Ther. 2018 Aug;16(8):655-661. doi: 10.1080/14787210.2018.1500457. Epub 2018 Jul 17. PMID: 30003818.

6: Jumani RS, Bessoff K, Love MS, Miller P, Stebbins EE, Teixeira JE, Campbell MA, Meyers MJ, Zambriski JA, Nunez V, Woods AK, McNamara CW, Huston CD. A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01505-17. doi: 10.1128/AAC.01505-17. PMID: 29339392; PMCID: PMC5913971.

7: Stebbins E, Jumani RS, Klopfer C, Barlow J, Miller P, Campbell MA, Meyers MJ, Griggs DW, Huston CD. Clinical and microbiologic efficacy of the piperazine- based drug lead MMV665917 in the dairy calf cryptosporidiosis model. PLoS Negl Trop Dis. 2018 Jan 8;12(1):e0006183. doi: 10.1371/journal.pntd.0006183. PMID: 29309415; PMCID: PMC5774826.