Orazipone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414600

CAS#: 137109-78-5

Description: Orazipone inhibits cytokine production and histamine release; an NSAID.

Chemical Structure

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Orazipone
CAS# 137109-78-5
Instruction

Theoretical Analysis

MedKoo Cat#: 414600
Name: Orazipone
CAS#: 137109-78-5
Chemical Formula: C13H14O4S
Exact Mass: 266.06
Molecular Weight: 266.310
Elemental Analysis: C, 58.63; H, 5.30; O, 24.03; S, 12.04

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Orazipone; OR-1384; OR1384; OR 1384

IUPAC/Chemical Name: 3-(p-(Methylsulfonyl)benzylidene)-2,4-pentanedione

InChi Key: CAWYWWPWSAMGBV-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H14O4S/c1-9(14)13(10(2)15)8-11-4-6-12(7-5-11)18(3,16)17/h4-8H,1-3H3

SMILES Code: CC(/C(C(C)=O)=C/C1=CC=C(S(=O)(C)=O)C=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 266.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sareila O, Hämäläinen M, Nissinen E, Kankaanranta H, Moilanen E. Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli. J Pharmacol Exp Ther. 2008 Feb;324(2):858-66. doi: 10.1124/jpet.107.129114. Epub 2007 Nov 26. PMID: 18039960.

2: Boerma M, Wang J, Richter KK, Hauer-Jensen M. Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model. Int J Radiat Oncol Biol Phys. 2006 Oct 1;66(2):552-9. doi: 10.1016/j.ijrobp.2006.05.067. PMID: 16965997.

3: Kankaanranta H, Ilmarinen P, Zhang X, Nissinen E, Moilanen E. Antieosinophilic activity of orazipone. Mol Pharmacol. 2006 Jun;69(6):1861-70. doi: 10.1124/mol.105.021170. Epub 2006 Mar 15. PMID: 16540599.

4: Vendelin J, Laitinen C, Vainio PJ, Nissinen E, Mäki T, Eklund KK. Novel sulfhydryl-reactive compounds orazipone and OR-1958 inhibit cytokine production and histamine release in rat and human mast cells. Int Immunopharmacol. 2005 Jan;5(1):177-84. doi: 10.1016/j.intimp.2004.07.020. PMID: 15589479.