Norletimol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414477

CAS#: 886-08-8

Description: Norletimol is a Schiff base with promising anti-inflammatory properties. The time taken for elimination of 50% of the Norletimol dose in the urine was approximately five hours. As an antirheumatic agent it was tested in clinical trials in Iraq. It was used in progressive myopia in children.

Chemical Structure

img
Norletimol
CAS# 886-08-8
Instruction

Theoretical Analysis

MedKoo Cat#: 414477
Name: Norletimol
CAS#: 886-08-8
Chemical Formula: C14H13NO
Exact Mass: 211.10
Molecular Weight: 211.260
Elemental Analysis: C, 79.59; H, 6.20; N, 6.63; O, 7.57

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Norletimol; NSC128931; NSC-128931; NSC 128931

IUPAC/Chemical Name: N-(2-Hydroxybenzylidene)benzylamine

InChi Key: LPSMMAHYAIVSQW-RVDMUPIBSA-N

InChi Code: InChI=1S/C14H13NO/c16-14-9-5-4-8-13(14)11-15-10-12-6-2-1-3-7-12/h1-9,11,16H,10H2/b15-11+

SMILES Code: OC1=CC=CC=C1/C=N/CC2=CC=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 211.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Al-Ani MR, Wood SG, Lawson A. The metabolism of saddamine in man: the fate of the benzylamine moiety of saddamine. Eur J Drug Metab Pharmacokinet. 1979;4(2):117-9. doi: 10.1007/BF03189411. PMID: 488132.

2: Riddle JA, Bollinger JC, Lee D. Escape from a nonporous solid: mechanically coupled biconcave molecules. Angew Chem Int Ed Engl. 2005 Oct 21;44(41):6689-93. doi: 10.1002/anie.200501888. PMID: 16173003.

3: Al-Ani MR, Wood SG, Lawson A. Comparison of the major urinary metabolites of saddamine and aspirin using thin-layer chromatography. J Chromatogr. 1978 Dec 11;166(2):626-31. doi: 10.1016/s0021-9673(00)95652-8. PMID: 748364.

4: Kirkpatrick D, Hawkins DR, Chasseaud LF, Finn CM, Conway B, Al-Ani MR, Al- Sayyab AF. The metabolism of salicylidene benzylamine, a pro-drug for salicylate, in rats and dogs. Xenobiotica. 1983 Jan;13(1):53-64. doi: 10.3109/00498258309052215. PMID: 6858201.

5: Wood SG, Al-Ani MR, Lawson A. GLC determination of purity of Schiff bases bakrine and saddamine. J Pharm Sci. 1979 Mar;68(3):374-6. doi: 10.1002/jps.2600680334. PMID: 423134.

6: Korzekwa A, Szymankiewiczowa S. Leczenie postepujacej krótkowzroczności u dzieci jonoforeza sadaminowo-wapniowa i difrarelem [Treatment of progressive myopia in children by saddamine and calcium iontophoresis and difrarel]. Klin Oczna. 1985 Aug;87(8):322-3. Polish. PMID: 3831573.