Nolotil

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414452

CAS#: 54017-59-3

Description: Nolotil is a painkiller, spasm reliever, and fever reliever that also has anti-inflammatory effects. It is most commonly given by mouth or by injection.

Chemical Structure

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Nolotil
CAS# 54017-59-3
Instruction

Theoretical Analysis

MedKoo Cat#: 414452
Name: Nolotil
CAS#: 54017-59-3
Chemical Formula: C26H32MgN6O8S2
Exact Mass: 644.16
Molecular Weight: 645.000
Elemental Analysis: C, 48.42; H, 5.00; Mg, 3.77; N, 13.03; O, 19.84; S, 9.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Nolotil; Metamizole

IUPAC/Chemical Name: magnesium ((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino)methanesulfonate

InChi Key: NHMUJYOBLYTIKO-UHFFFAOYSA-L

InChi Code: InChI=1S/2C13H17N3O4S.Mg/c2*1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;/h2*4-8H,9H2,1-3H3,(H,18,19,20);/q;;+2/p-2

SMILES Code: CN(C1=C(N(N(c2ccccc2)C1=O)C)C)CS(=O)(O[Mg]OS(=O)(CN(C3=C(N(N(c4ccccc4)C3=O)C)C)C)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 645.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dalmau J, Serra-Baldrich E, Roé E, Peramiquel L, Alomar A. Use of patch test in fixed drug eruption due to metamizole (Nolotil). Contact Dermatitis. 2006 Feb;54(2):127-8. doi: 10.1111/j.0105-1873.2006.0560i.x. PMID: 16487292.

2: Ortiz-Gómez JR, Perepérez-Candel M, Vázquez-Torres JM, Rodriguez-Del Río JM, Torrón-Abad B, Fornet-Ruiz I, Palacio-Abizanda FJ. Postoperative analgesia for elective total knee arthroplasty under subarachnoid anesthesia with opioids: comparison between epidural, femoral block and adductor canal block techniques (with and without perineural adjuvants). A prospective, randomized, clinical trial. Minerva Anestesiol. 2017 Jan;83(1):50-58. doi: 10.23736/S0375-9393.16.11646-3. Epub 2016 Oct 28. PMID: 27792212.

3: Hopen G, Ly B, Moen T. Agranulocytose etter bruk av utenlandske "hodepinetabletter" (Optalidon og Nolotil) [Agranulocytosis caused by foreign analgesics (Optalidon and Nolotil)]. Tidsskr Nor Laegeforen. 1979 May 10;99(13):635. Norwegian. PMID: 451964.

4: Criado A, Domínguez E, García Cubero A, López A, Navarro E. Shock anafiláctico y parada cardíaca por administración endovenosa de nolotil [Anaphylactic shock and cardiac arrest by intravenous administration of nolotil]. Rev Esp Anestesiol Reanim. 1979 Nov;26(6):600-3. Spanish. PMID: 547318.

5: Marín-Bertolín S, De Andrés J, González-Martínez R, Valia Vera JC, Amorrortu- Velayos J. A controlled, randomized, double-blind study of ketorolac for postoperative analgesia after plastic surgery. Ann Plast Surg. 1997 May;38(5):478-84. PMID: 9160129.

6: Ibáñez L, Vidal X, Ballarín E, Laporte JR. Population-based drug-induced agranulocytosis. Arch Intern Med. 2005 Apr 25;165(8):869-74. doi: 10.1001/archinte.165.8.869. PMID: 15851637.

7: Bellens JJ. Livstruende forgiftning med udenlandsk håndkøbsmedicin (Nolotil) [Life endangering poisoning with a foreign patent medicine (Nolotil)]. Ugeskr Laeger. 1976 Nov 29;138(49):3123-4. Danish. PMID: 996950.

8: Martin-Garcia C, Martinez-Borque N, Martinez-Bohigas D, Torrecillas-Toro M, Palomeque-Rodrìguez MT. Delayed reaction urticaria due to trimebutine. Allergy. 2004 Jul;59(7):789-90. doi: 10.1111/j.1398-9995.2004.00443.x. PMID: 15180771.

9: Calvo Vecino JM, San Norberto L, Abad Gurumeta A, Velasco Villanueva D, Velásquez Muñoz MF, Pico Brezmes S, Pérez Gallardo A. Levobupivacaína versus bupivacaína racémica para anestesia/analgesia epidural toráicica y lumbar alta en niños [Levobupivacaine versus racemic bupivacaine for thoracic and upper lumbar epidural anesthesia-analgesia in children]. Rev Esp Anestesiol Reanim. 2007 May;54(5):288-96. Spanish. PMID: 17598719.

10: R Ortiz-Gómez J, Perepérez-Candel M, Pavón-Benito A, Torrón-Abad B, Dorronsoro-Auzmendi M, Martínez-García Ó, Zabaleta-Zúñiga AR, Azcona-Calahorra MA, Fornet-Ruiz I, Ortiz-Domínguez A, Palacio-Abizanda FJ. A randomized clinical trial comparing six techniques of postoperative analgesia for elective total hip arthroplasty under subarachnoid anesthesia with opioids. Minerva Anestesiol. 2021 Jun;87(6):663-674. doi: 10.23736/S0375-9393.21.14957-0. Epub 2021 Feb 16. PMID: 33591141.