VZN-80448
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464835

CAS#: 62480-44-8

Description: VZN-80448 is a fluorogenic substrate for leucine aminopeptidase. Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

img
VZN-80448
CAS# 62480-44-8
Instruction

Theoretical Analysis

MedKoo Cat#: 464835
Name: VZN-80448
CAS#: 62480-44-8
Chemical Formula: C16H21ClN2O3
Exact Mass: 0.00
Molecular Weight: 324.805
Elemental Analysis: C, 59.17; H, 6.52; Cl, 10.91; N, 8.62; O, 14.78

Price and Availability

Size Price Availability Quantity
10mg USD -2 2 Weeks
25mg USD -2 2 Weeks
1g USD -2 2 Weeks
2g USD -2 2 Weeks
5g USD -2 2 Weeks
50mg USD 270 2 Weeks
100mg USD 450 2 Weeks
250mg USD 810 2 Weeks
500mg USD 1270 2 Weeks
Bulk inquiry

Synonym: VZN-80448; VZN 80448; VZN80448; L-Leu-AMC HCl; L-Leu-AMC hydrochloride;

IUPAC/Chemical Name: (S)-2-amino-4-methyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanamide hydrochloride

InChi Key: VCRXITKKWBOQRZ-ZOWNYOTGSA-N

InChi Code: InChI=1S/C16H20N2O3.ClH/c1-9(2)6-13(17)16(20)18-11-4-5-12-10(3)7-15(19)21-14(12)8-11;/h4-5,7-9,13H,6,17H2,1-3H3,(H,18,20);1H/t13-;/m0./s1

SMILES Code: CC(C1=CC=C(C=C1O2)NC([C@H](CC(C)C)N)=O)=CC2=O.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 25.0 76.97
DMSO 25.0 76.97
DMSO:PBS (pH 7.2) (1:3) 0.3 0.77

Preparing Stock Solutions

The following data is based on the product molecular weight 324.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Cheng T, Chepkirui C, Decock C, Matasyoh JC, Stadler M. Skeletocutins M-Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa. Beilstein J Org Chem. 2019 Nov 19;15:2782-2789. doi: 10.3762/bjoc.15.270. PMID: 31807212; PMCID: PMC6880814.