AZD8154
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464776

CAS#: 2215022-45-8

Description: AZD8154 is a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.

Chemical Structure

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AZD8154
CAS# 2215022-45-8
Instruction

Theoretical Analysis

MedKoo Cat#: 464776
Name: AZD8154
CAS#: 2215022-45-8
Chemical Formula: C27H29N5O4S2
Exact Mass: 551.17
Molecular Weight: 551.680
Elemental Analysis: C, 58.78; H, 5.30; N, 12.69; O, 11.60; S, 11.62

Price and Availability

Size Price Availability Quantity
5mg USD 950 2 Weeks
10mg USD 1650 2 Weeks
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Synonym: AZD8154; AZD 8154; AZD-8154;

IUPAC/Chemical Name: (S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino)thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one

InChi Key: XOMFDZJQLSPGGV-INIZCTEOSA-N

InChi Code: InChI=1S/C27H29N5O4S2/c1-15-25(37-27(28-15)30-21-6-4-7-22(29-21)31-11-5-8-23(31)33)18-12-19-14-32(16(2)17-9-10-17)26(34)24(19)20(13-18)38(3,35)36/h4,6-7,12-13,16-17H,5,8-11,14H2,1-3H3,(H,28,29,30)/t16-/m0/s1

SMILES Code: O=C1N([C@H](C2CC2)C)CC3=C1C(S(=O)(C)=O)=CC(C4=C(C)N=C(NC5=NC(N6C(CCC6)=O)=CC=C5)S4)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 551.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Perry MWD, Björhall K, Bold P, Brűlls M, Börjesson U, Carlsson J, Chang HA, Chen Y, Eriksson A, Fihn BM, Fransson R, Fredlund L, Ge H, Huang H, Karabelas K, Lamm Bergström E, Lever S, Lindmark H, Mogemark M, Nikitidis A, Palmgren AP, Pemberton N, Petersen J, Rodrigo Blomqvist M, Smith RW, Thomas MJ, Ullah V, Tyrchan C, Wennberg T, Westin Eriksson A, Yang W, Zhao S, Öster L. Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma. J Med Chem. 2021 Jun 3. doi: 10.1021/acs.jmedchem.1c00434. Epub ahead of print. PMID: 34080862.