Khelloside
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MedKoo CAT#: 414241

CAS#: 17226-75-4

Description: Khelloside is a component of Ammi visnaga L. fruits extract, a medicine which is used in Egypt as remedy for the treatment of kidney stones.

Chemical Structure

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Khelloside
CAS# 17226-75-4
Instruction

Theoretical Analysis

MedKoo Cat#: 414241
Name: Khelloside
CAS#: 17226-75-4
Chemical Formula: C19H20O10
Exact Mass: 408.11
Molecular Weight: 408.360
Elemental Analysis: C, 55.88; H, 4.94; O, 39.18

Price and Availability

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1mg USD 550 2 Weeks
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Synonym: Khelloside; NSC82907; NSC-82907; NSC 82907

IUPAC/Chemical Name: 5H-Furo(3,2-g)(1)benzopyran-5-one, 7-((beta-D-glucopyranosyloxy)methyl)-4-methoxy- (9CI)

InChi Key: SJRACCTZSAUMGO-WIMVFMHDSA-N

InChi Code: InChI=1S/C19H20O10/c1-25-18-9-2-3-26-11(9)5-12-14(18)10(21)4-8(28-12)7-27-19-17(24)16(23)15(22)13(6-20)29-19/h2-5,13,15-17,19-20,22-24H,6-7H2,1H3/t13-,15-,16+,17-,19-/m1/s1

SMILES Code: O=C1C=C(CO[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)OC3=CC(OC=C4)=C4C(OC)=C13

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 408.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Stevens TJ, Jones BW, Vidmar TJ, Moran JJ, Manni DS, Day CE. Hypocholesterolemic effect of khellin and khelloside in female cynomolgus monkeys. Arzneimittelforschung. 1985;35(8):1257-60. PMID: 3865654.

2: Badr JM, Hadad GM, Nahriry K, Hassanean HA. Validated HPLC method for simultaneous estimation of khellol glucoside, khellin and visnagin in Ammi visnaga L. fruits and pharmaceutical preparations. Nat Prod Res. 2015;29(7):593-601. doi: 10.1080/14786419.2014.945170. Epub 2014 Aug 11. PMID: 25111086.

3: CLOETENS W, DE MEY D. Utilisation clinique du khellol-glucoside [Clinical use of khellol-glucoside]. Brux Med. 1954 Aug 15;34(33):1565-74. French. PMID: 13190260.

4: BARAKAT MZ, BADRAN N. New tests for the identification of khellin, visnagin and khellol-glucoside. J Pharm Pharmacol. 1951 Sep;3(9):576-80. doi: 10.1111/j.2042-7158.1951.tb13102.x. PMID: 14874194.

5: MELON JM. Traitement de l'angor coronarien par le khellol-glucoside [Treatment of angina pectoris with khellol-glucoside]. Brux Med. 1957 Apr 21;37(16):617-22. French. PMID: 13436895.