Irsogladine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576766

CAS#: 57381-26-7

Description: Irsogladine is an anti-ulcer and antineoplastic agent.

Chemical Structure

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Irsogladine
CAS# 57381-26-7
Instruction

Theoretical Analysis

MedKoo Cat#: 576766
Name: Irsogladine
CAS#: 57381-26-7
Chemical Formula: C9H7Cl2N5
Exact Mass: 255.01
Molecular Weight: 256.090
Elemental Analysis: C, 42.21; H, 2.76; Cl, 27.69; N, 27.35

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Irsogladine

IUPAC/Chemical Name: 2,4-Diamino-6-(2,5-dichlorophenyl)-s-triazine

InChi Key: ATCGGEJZONJOCL-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H7Cl2N5/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7/h1-3H,(H4,12,13,14,15,16)

SMILES Code: Nc1nc(N)nc(n1)c2cc(Cl)ccc2Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 256.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Shim KN, Kim JI, Kim N, Kim SG, Jo YJ, Hong SJ, Shin JE, Kim GH, Park KS, Choi SC, Kwon JG, Kim JH, Kim HJ, Kim JW. The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis. Korean J Intern Med. 2019 Sep;34(5):1008-1021. doi: 10.3904/kjim.2017.370. Epub 2018 Jun 1. PMID: 29847892; PMCID: PMC6718769.

2. Akagi M, Amagase K, Murakami T, Takeuchi K. Irsogladine: overview of the mechanisms of mucosal protective and healing- promoting actions in the gastrointestinal tract. Curr Pharm Des. 2013;19(1):106-14. doi: 10.2174/13816128130115. PMID: 22950502.

3 Isomura Y, Yamaji Y, Yamada A, Watanabe Y, Suzuki H, Kobayashi Y, Yoshida S, Watabe H, Hirata Y, Yoshida H, Koike K. Irsogladine improves small-intestinal injuries in regular users of nonsteroidal anti-inflammatory drugs. Gastrointest Endosc. 2014 Jul;80(1):118-25. doi: 10.1016/j.gie.2013.12.030. Epub 2014 Feb 8. PMID: 24518124.

4. Kyoi T, Noda K, Oka M, Ukai Y. Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci. 2004 Nov 19;76(1):71-83. doi: 10.1016/j.lfs.2004.06.016. PMID: 15501481.

5. Nanke Y, Kamatani N, Okamoto T, Ogiuchi H, Kotake S. Irsogladine is effective for recurrent oral ulcers in patients with Behçet's disease : an open-label, single-centre study. Drugs R D. 2008;9(6):455-9. doi: 10.2165/0126839-200809060-00008. PMID: 18989994.