DQ 2556

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413916

CAS#: 102253-70-3

Description: DQ 2556 is a recently developed cephalosporin with a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria. I

Chemical Structure

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DQ 2556
CAS# 102253-70-3
Instruction

Theoretical Analysis

MedKoo Cat#: 413916
Name: DQ 2556
CAS#: 102253-70-3
Chemical Formula: C22H19N7O6S2
Exact Mass: 541.08
Molecular Weight: 541.560
Elemental Analysis: C, 48.79; H, 3.54; N, 18.11; O, 17.73; S, 11.84

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DQ 2556; DQ-2556; DQ2556

IUPAC/Chemical Name: Pyridinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-4-(5-oxazolyl)-, hydroxide, inner salt, (6R-(6-alpha,7-beta(Z)))-

InChi Key: IWIVCNVLSKNJJS-HOHIPHJJSA-N

InChi Code: InChI=1S/C22H19N7O6S2/c1-34-27-15(13-9-37-22(23)25-13)18(30)26-16-19(31)29-17(21(32)33)12(8-36-20(16)29)7-28-4-2-11(3-5-28)14-6-24-10-35-14/h2-6,9-10,16,20H,7-8H2,1H3,(H3-,23,25,26,30,32,33)/b27-15-/t16-,20-/m0/s1

SMILES Code: O=C1[C@H](NC(/C(C2=CSC(N)=N2)=N\OC)=O)[C@]3([H])SCC(C[N+]4=CC=C(C5=CN=CO5)C=C4)=C(C([O-])=O)N13

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 541.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tanaka M, Otsuki M, Nishino T. In vitro and in vivo activities of DQ-2556 and its mode of action. Antimicrob Agents Chemother. 1992 Dec;36(12):2595-601. doi: 10.1128/aac.36.12.2595. PMID: 1482128; PMCID: PMC245513.

2: Sokol PP. Effect of DQ-2556, a new cephalosporin, on organic ion transport in renal plasma membrane vesicles from the dog, rabbit and rat. J Pharmacol Exp Ther. 1990 Nov;255(2):436-41. PMID: 2147035.

3: Fujimoto T, Watanabe M, Inoue M, Mitsuhashi S. In-vitro antibacterial activity of DQ-2556 and its stability to various beta-lactamases. J Antimicrob Chemother. 1990 Sep;26(3):329-41. doi: 10.1093/jac/26.3.329. PMID: 2228824.

4: Ishida Y, Miyazaki S, Yamaguchi K, Goto S. In vitro and in vivo activity of DQ-2556, a new cephalosporin. Chemotherapy. 1995 Jan-Feb;41(1):5-13. doi: 10.1159/000239318. PMID: 7875022.

5: Shiba K, Yoshida M, Shimada J, Saito A, Matsubayashi K, Hashimoto S, Yoshida K, Osada Y, Sakai O. Effect of probenecid on the pharmacokinetics of DQ-2556, a new 3-quaternary ammonium cephalosporin antibiotic, in humans. Chemotherapy. 1992;38(6):369-75. doi: 10.1159/000239029. PMID: 1288960.

6: Matsubayashi K, Shintani S, Yoshioka M, Tachizawa H. Metabolic disposition of DQ-2556, a new cephalosporin, in rats, rabbits, dogs, and monkeys. Antimicrob Agents Chemother. 1992 May;36(5):966-72. doi: 10.1128/aac.36.5.966. PMID: 1510421; PMCID: PMC188793.

7: Matsubayashi K, Shintani S, Yoshida K, Yamada M, Tachizawa H. Nonlinear pharmacokinetics of DQ-2556, a new 3-quaternary ammonium cephalosporin antibiotic, in rats caused by non-Michaelis-Menten type, dose-dependent renal clearance. J Pharm Sci. 1994 Feb;83(2):186-92. doi: 10.1002/jps.2600830214. PMID: 8169786.

8: Yasuda J, Yamamoto T, Okada H. [Pharmacokinetic and clinical studies on DQ-2556 in the gynecological field]. Jpn J Antibiot. 1993 Jan;46(1):67-74. Japanese. PMID: 8455333.

9: Kato M, Yoshida M, Shimada H, Akahane K, Takayama S. Nephrotoxicity of a new cephalosporin, DQ-2556, in rats. Fundam Appl Toxicol. 1992 May;18(4):532-9. doi: 10.1016/0272-0590(92)90112-u. PMID: 1526365.

10: Fujimoto T, Otani T, Nakajima R, Une T, Osada Y. In vitro activity of DQ-2556, a new cephalosporin. Antimicrob Agents Chemother. 1986 Oct;30(4):611-3. doi: 10.1128/aac.30.4.611. PMID: 3539013; PMCID: PMC176491.