Doxylamine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413903

CAS#: 469-21-6

Description: Doxylamine is a Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in PARKINSONISM.

Chemical Structure

img
Doxylamine
CAS# 469-21-6
Instruction

Theoretical Analysis

MedKoo Cat#: 413903
Name: Doxylamine
CAS#: 469-21-6
Chemical Formula: C17H22N2O
Exact Mass: 270.17
Molecular Weight: 270.380
Elemental Analysis: C, 75.52; H, 8.20; N, 10.36; O, 5.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Doxylamine; HSDB5184; HSDB-5184; HSDB 5184

IUPAC/Chemical Name: 2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine

InChi Key: HCFDWZZGGLSKEP-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3

SMILES Code: CC(C1=NC=CC=C1)(OCCN(C)C)C2=CC=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 270.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Doxylamine/pyridoxine for nausea and vomiting in pregnancy. Drug Ther Bull. 2019 Mar;57(3):38-41. doi: 10.1136/dtb.2018.000053. Epub 2019 Jan 31. PMID: 30705026.

2: Brott NR, Reddivari AKR. Doxylamine. 2021 Jan 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 31869110.

3: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Doxylamine. 2017 Jan 16. PMID: 31644135.

4: Persaud N, Meaney C, El-Emam K, Moineddin R, Thorpe K. Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis. PLoS One. 2018 Jan 17;13(1):e0189978. doi: 10.1371/journal.pone.0189978. PMID: 29342163; PMCID: PMC5771578.

5: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Doxylamine. 2018 Dec 3. PMID: 29999680.

6: Burchakov DI. Doksilamin i melatonin v korrektsii narusheniĭ sna v ginekologicheskoĭ praktike [Doxylamine and melatonin in treatment of sleep disruption in gynecological practice]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(4. Vyp. 2):67-72. Russian. doi: 10.17116/jnevro20181184267. PMID: 30059054.

7: Abraham O, Schleiden L, Albert SM. Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep. Int J Clin Pharm. 2017 Aug;39(4):808-817. doi: 10.1007/s11096-017-0467-x. Epub 2017 May 2. PMID: 28466395; PMCID: PMC5541127.

8: Abramowitz A, Miller ES, Wisner KL. Treatment options for hyperemesis gravidarum. Arch Womens Ment Health. 2017 Jun;20(3):363-372. doi: 10.1007/s00737-016-0707-4. Epub 2017 Jan 9. PMID: 28070660; PMCID: PMC7037589.

9: Hung CH, Shieh JP, Chiu CC, Wang JJ, Chen YW. Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats. Pharmacol Rep. 2018 Jun;70(3):565-569. doi: 10.1016/j.pharep.2017.12.006. Epub 2017 Dec 20. PMID: 29679880.

10: Drugs for chronic insomnia. Med Lett Drugs Ther. 2018 Dec 17;60(1562):201-205. PMID: 30625122.