BMV109

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464573

CAS#: 1458731-58-2

Description: BMV109 is a novel fluorescent activity-based probe (ABP), being intrinsically "dark" and only emitting fluorescence after reaction with the target protease, are ideally suited for imaging techniques such as small animal noninvasive fluorescence imaging and live cell fluorescence microscopy.

Chemical Structure

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BMV109
CAS# 1458731-58-2
Instruction

Theoretical Analysis

MedKoo Cat#: 464573
Name: BMV109
CAS#: 1458731-58-2
Chemical Formula: C107H108F4N10O23S5
Exact Mass: 2,136.61
Molecular Weight: 2,138.382
Elemental Analysis: C, 60.10; H, 5.09; F, 3.55; N, 6.55; O, 17.21; S, 7.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BMV109; BMV-109; BMV 109;

IUPAC/Chemical Name: 1-((E)-9-(2-((4-((2-(4-(((S)-7-(6-((E)-2-((2E,4E)-5-(5-((l1-oxidaneyl)dioxo-l6-sulfaneyl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium-2-yl)penta-2,4-dien-1-ylidene)-3,3-dimethyl-5-sulfoindolin-1-yl)hexanamido)-3-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-2-oxoheptyl)oxy)-2,3,5,6-tetrafluorobenzamido)ethyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)-6-(5-sulfoindolin-1-yl)-3H-xanthen-3-ylidene)-1l4-indoline-5-sulfonate

InChi Key: KDFGXWUMTFTKSD-XYZCXLSZSA-N

InChi Code: InChI=1S/C107H108F4N10O23S5/c1-6-118-86-43-37-75(148(136,137)138)62-80(86)106(2,3)92(118)30-15-9-16-31-93-107(4,5)81-63-76(149(139,140)141)38-44-87(81)121(93)52-22-10-17-32-94(123)112-49-21-20-28-82(115-103(125)83(57-66-23-11-7-12-24-66)116-105(127)143-64-67-25-13-8-14-26-67)88(122)65-142-101-99(110)97(108)96(98(109)100(101)111)104(126)114-51-50-113-102(124)68-45-53-117(54-46-68)145(128,129)91-29-19-18-27-79(91)95-77-39-33-71(119-55-47-69-58-73(146(130,131)132)35-41-84(69)119)60-89(77)144-90-61-72(34-40-78(90)95)120-56-48-70-59-74(147(133,134)135)36-42-85(70)120/h7-9,11-16,18-19,23-27,29-31,33-44,58-63,68,82-83H,6,10,17,20-22,28,32,45-57,64-65H2,1-5H3,(H7-2,112,113,114,115,116,123,124,125,126,127,130,131,132,133,134,135,136,137,138,139,140,141)/t82-,83-/m0/s1

SMILES Code: O=S(C1=CC2=C(/[N+](CC2)=C3C=CC4=C(C5=CC=CC=C5S(=O)(N6CCC(C(NCCNC(C7=C(F)C(F)=C(OCC([C@@H](NC([C@@H](NC(OCC8=CC=CC=C8)=O)CC9=CC=CC=C9)=O)CCCCNC(CCCCCN%10/C(C(C)(C)C%11=C%10C=CC(S(=O)(O)=O)=C%11)=C/C=C/C=C/C%12=[N+](CC)C%13=C(C=C(S(=O)([O-])=O)C=C%13)C%12(C)C)=O)=O)C(F)=C7F)=O)=O)CC6)=O)C%14=C(C=C(N%15CCC%16=C%15C=CC(S(=O)(O)=O)=C%16)C=C%14)OC4=C\3)C=C1)([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 2,138.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Flanagan-Steet H, Christian C, Lu PN, Aarnio-Peterson M, Sanman L, Archer- Hartmann S, Azadi P, Bogyo M, Steet RA. TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development. Cell Rep. 2018 Mar 13;22(11):2964-2977. doi: 10.1016/j.celrep.2018.02.066. PMID: 29539424; PMCID: PMC6247414.

2: Sensarn S, Zavaleta CL, Segal E, Rogalla S, Lee W, Gambhir SS, Bogyo M, Contag CH. A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer. Mol Imaging Biol. 2016 Dec;18(6):820-829. doi: 10.1007/s11307-016-0956-7. PMID: 27154508; PMCID: PMC5564400.

3: Edgington-Mitchell LE, Bogyo M, Verdoes M. Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe. Methods Mol Biol. 2017;1491:145-159. doi: 10.1007/978-1-4939-6439-0_11. PMID: 27778287.

4: Withana NP, Saito T, Ma X, Garland M, Liu C, Kosuge H, Amsallem M, Verdoes M, Ofori LO, Fischbein M, Arakawa M, Cheng Z, McConnell MV, Bogyo M. Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation. J Nucl Med. 2016 Oct;57(10):1583-1590. doi: 10.2967/jnumed.115.171553. Epub 2016 May 19. PMID: 27199363; PMCID: PMC5367444.

5: Ahmad H, Gupta V, Dwivedi AP, Katti SB, Dwivedi AK. Chiral Separation of Ormeloxifene Hydrochloride, a Non-steroidal Contraceptive Agent. J Chromatogr Sci. 2016 Feb;54(2):125-9. doi: 10.1093/chromsci/bmv109. Epub 2015 Aug 1. PMID: 26233489.

6: Segal E, Prestwood TR, van der Linden WA, Carmi Y, Bhattacharya N, Withana N, Verdoes M, Habtezion A, Engleman EG, Bogyo M. Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins. Chem Biol. 2015 Jan 22;22(1):148-58. doi: 10.1016/j.chembiol.2014.11.008. Epub 2015 Jan 8. PMID: 25579207; PMCID: PMC4353655.