Belladonnine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413845

CAS#: 510-25-8

Description: Belladonnine is a member of class of tropane alkaloids. Belladonnine can be found in plants of family Solanaceae. Commercially available preparations called "belladonnine" are sometimes a mixture of this chemical with atropine. β-Belladonnine selectively blocks heart M-receptors (ED50: 13 μg/kg): a blockage of smooth muscles and secretory organs M-cholinoreceptors requires a 10 to 20 times higher concentration. β-Belladonnine also blocks skeletal muscles N-cholinoreceptors (ED50: 50-60 mg/kg).

Chemical Structure

img
Belladonnine
CAS# 510-25-8
Instruction

Theoretical Analysis

MedKoo Cat#: 413845
Name: Belladonnine
CAS#: 510-25-8
Chemical Formula: C34H42N2O4
Exact Mass: 542.31
Molecular Weight: 542.720
Elemental Analysis: C, 75.25; H, 7.80; N, 5.16; O, 11.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Belladonnine; Isatropylditropeine; Tropyl isatropate

IUPAC/Chemical Name: 1,4-Naphthalenedicarboxylic acid, 1,2,3,4-tetrahydro-1-phenyl-, bis(8-methyl-8-azabicyclo(3.2.1)oct-3-yl) ester

InChi Key: GERIGMSHTUAXSI-UHFFFAOYSA-N

InChi Code: InChI=1S/C34H42N2O4/c1-35-23-12-13-24(35)19-27(18-23)39-32(37)30-16-17-34(22-8-4-3-5-9-22,31-11-7-6-10-29(30)31)33(38)40-28-20-25-14-15-26(21-28)36(25)2/h3-11,23-28,30H,12-21H2,1-2H3

SMILES Code: O=C(C1(C2=CC=CC=C2)CCC(C(OC3CC(N4C)CCC4C3)=O)C5=C1C=CC=C5)OC6CC(N7C)CCC7C6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 542.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: ROSENBLUM EI, TAYLOR WS. The detection of apoatropine and belladonnine in atropine. J Pharm Pharmacol. 1955 Dec;7(12):1067-71. doi: 10.1111/j.2042-7158.1955.tb12119.x. PMID: 13278854.

2: Maurya VK, Kumar S, Bhatt MLB, Saxena SK. Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection. J Biomol Struct Dyn. 2020 Oct 19:1-17. doi: 10.1080/07391102.2020.1832577. Epub ahead of print. PMID: 33073699; PMCID: PMC7597308.

3: HOTOVY R. Zur Pharmakologie des Belladonnins [Pharmacology of belladonnine]. Arzneimittelforschung. 1954 Apr;4(4):287-92. Undetermined Language. PMID: 13159731.

4: HOTOVY R, KAPFF-WALTER J, FIEBIG L. [Modification of the local analgesic action of local anesthetics by belladonnine sulfate]. Arch Int Pharmacodyn Ther. 1962 Sep 1;139:281-300. German. PMID: 13955008.

5: Arráez-Román D, Zurek G, Bässmann C, Segura-Carretero A, Fernández-Gutiérrez A. Characterization of Atropa belladonna L. compounds by capillary electrophoresis-electrospray ionization-time of flight-mass spectrometry and capillary electrophoresis-electrospray ionization-ion trap-mass spectrometry. Electrophoresis. 2008 May;29(10):2112-6. doi: 10.1002/elps.200700468. PMID: 18425749.

6: IMO K. Uber Belladonninbromäthylat (C 100), ein neues Muskelrelaxans [Belladonnine bromethylate (C100), a new muscle relaxant]. Anaesthesist. 1954 Jun;3(3):116-8. German. PMID: 13207708.

7: WAALER T, BJERKELUND E. DIE SPEKTROPHOTOMETRISCHE BESTIMMUNG VON APOATROPIN UND BELLADONNIN IN ATROPIN [THE SPECTROPHOTOMETRIC DETERMINATION OF APOATROPINE AND BELLADONNINE IN ATROPINE]. Pharm Acta Helv. 1964 Mar;39:150-4. German. PMID: 14241289.