ICI-105552

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576474

CAS#: 81420-31-7

Description: ICI-105552 is an aldose reductase inhibitor.


Chemical Structure

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ICI-105552
CAS# 81420-31-7

Theoretical Analysis

MedKoo Cat#: 576474
Name: ICI-105552
CAS#: 81420-31-7
Chemical Formula: C19H14Cl2NNaO3
Exact Mass: 397.0248
Molecular Weight: 398.21
Elemental Analysis: C, 57.31; H, 3.54; Cl, 17.80; N, 3.52; Na, 5.77; O, 12.05

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICI-105552; ICI105552; ICI 105552

IUPAC/Chemical Name: 4-Quinolineacetic acid, 1-((3,4-dichlorophenyl)methyl)-1,2-dihydro-3-methyl-2-oxo-, sodium salt

InChi Key: AGXORWCKWUILLU-UHFFFAOYSA-M

InChi Code: InChI=1S/C19H15Cl2NO3.Na/c1-11-14(9-18(23)24)13-4-2-3-5-17(13)22(19(11)25)10-12-6-7-15(20)16(21)8-12;/h2-8H,9-10H2,1H3,(H,23,24);/q;+1/p-1

SMILES Code: [Na+].CC1=C(CC(=O)[O-])c2ccccc2N(Cc3ccc(Cl)c(Cl)c3)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 398.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1. Bhatnagar A, Liu SQ, Das B, Ansari NH, Srivastava SK. Inhibition kinetics of human kidney aldose and aldehyde reductases by aldose reductase inhibitors. Biochem Pharmacol. 1990 Mar 15;39(6):1115-24. doi: 10.1016/0006-2952(90)90292-s. PMID: 2157439.

2. Poulsom R, Mirrlees DJ, Earl DC, Heath H. The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats. Exp Eye Res. 1983 May;36(5):751-60. doi: 10.1016/0014-4835(83)90112-4. PMID: 6406254.

3. Poulsom R, Heath H. Inhibition of aldose reductase in five tissues of the streptozotocin-diabetic rat. Biochem Pharmacol. 1983 May 1;32(9):1495-9. doi: 10.1016/0006-2952(83)90471-9. PMID: 6407486.