Hydrochlorothiazide HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576436

CAS#: 42461-28-9

Description: Hydrochlorothiazide HCl is a thiazide diuretic often used to treat high blood pressure and swelling due to fluid build up. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.

Chemical Structure

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Hydrochlorothiazide HCl
CAS# 42461-28-9
Instruction

Theoretical Analysis

MedKoo Cat#: 576436
Name: Hydrochlorothiazide HCl
CAS#: 42461-28-9
Chemical Formula: C7H9Cl2N3O4S2
Exact Mass: 332.94
Molecular Weight: 334.190
Elemental Analysis: C, 25.16; H, 2.71; Cl, 21.22; N, 12.57; O, 19.15; S, 19.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Hydrochlorothiazide hydrochloride; Hydrochlorothiazide HCl

IUPAC/Chemical Name: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide, hydrochloride

InChi Key: HNLAFWZKHCUIMC-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H8ClN3O4S2.ClH/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5;/h1-2,10-11H,3H2,(H2,9,12,13);1H

SMILES Code: Cl.NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 334.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dinç E, Ertekin ZC. Three-way analysis of the UPLC-PDA dataset for the multicomponent quantitation of hydrochlorothiazide and olmesartan medoxomil in tablets by parallel factor analysis and three-way partial least squares. Talanta. 2016 Feb 1;148:144-52. doi: 10.1016/j.talanta.2015.10.074. Epub 2015 Oct 26. PubMed PMID: 26653435.

2: Machnicki G, Ong SH, Chen W, Wei ZJ, Kahler KH. Comparison of amlodipine/valsartan/hydrochlorothiazide single pill combination and free combination: adherence, persistence, healthcare utilization and costs. Curr Med Res Opin. 2015 Dec;31(12):2287-96. doi: 10.1185/03007995.2015.1098598. Epub 2015 Nov 11. PubMed PMID: 26397178.

3: Machini WB, David-Parra DN, Teixeira MF. Electrochemical investigation of the voltammetric determination of hydrochlorothiazide using a nickel hydroxide modified nickel electrode. Mater Sci Eng C Mater Biol Appl. 2015 Dec 1;57:344-8. doi: 10.1016/j.msec.2015.07.035. Epub 2015 Aug 11. PubMed PMID: 26354274.

4: Blatnik SU, Dreu R, Srčič S. Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets. Acta Pharm. 2015 Dec 1;65(4):383-97. doi: 10.1515/acph-2015-0031. PubMed PMID: 26677896.

5: Arafa MF, El-Gizawy SA, Osman MA, El Maghraby GM. Sucralose as co-crystal co-former for hydrochlorothiazide: development of oral disintegrating tablets. Drug Dev Ind Pharm. 2015 Dec 7:1-9. [Epub ahead of print] PubMed PMID: 26555927.