Isoxsuprine Free Base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413735

CAS#: 395-28-8 (free base)

Description: Isoxsuprine Free Base is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.

Chemical Structure

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Isoxsuprine Free Base
CAS# 395-28-8 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 413735
Name: Isoxsuprine Free Base
CAS#: 395-28-8 (free base)
Chemical Formula: C18H23NO3
Exact Mass: 301.17
Molecular Weight: 301.390
Elemental Analysis: C, 71.73; H, 7.69; N, 4.65; O, 15.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 395-28-8 (free)   579-56-6 (HCl)   58379-21-8 (lactate)  

Synonym: Isoxsuprine Free Base; Vasodilian; Vasosurpine

IUPAC/Chemical Name: Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-2-phenoxyethyl)amino)ethyl)-

InChi Key: BMUKKTUHUDJSNZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H23NO3/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15/h3-11,13-14,18-21H,12H2,1-2H3

SMILES Code: OC(C(NC(C)COC1=CC=CC=C1)C)C2=CC=C(O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 301.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Erkert RS, Macallister CG. Isoxsuprine hydrochloride in the horse: a review. J Vet Pharmacol Ther. 2002 Apr;25(2):81-7. doi: 10.1046/j.1365-2885.2002.00386.x. PMID: 12000527.

2: Shiri F, Shahraki S, Shahriyar A, Majd MH. Exploring isoxsuprine hydrochloride binding with human serum albumin in the presence of folic acid and ascorbic acid using multispectroscopic and molecular modeling methods. J Photochem Photobiol B. 2017 May;170:152-163. doi: 10.1016/j.jphotobiol.2017.04.007. Epub 2017 Apr 11. PMID: 28432945.

3: Jaju PB. Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active/Threatened Preterm Labor and Its Role in Maintenance Tocolysis: A Prospective, Open-Label Study. Am J Perinatol. 2021 Feb;38(3):291-295. doi: 10.1055/s-0039-1696720. Epub 2019 Sep 24. PMID: 31550735.

4: Medina-Ruiz D, Erreguin-Luna B, Luna-Vázquez FJ, Romo-Mancillas A, Rojas- Molina A, Ibarra-Alvarado C. Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H₂S/KATP Pathways and Blockade of α₁-Adrenoceptors and Calcium Channels. Molecules. 2019 Mar 11;24(5):987. doi: 10.3390/molecules24050987. PMID: 30862086; PMCID: PMC6429095.

5: Shahraki S, Delarami HS, Saeidifar M, Nejat R. Catalytic activity and structural changes of catalase in the presence of Levothyroxine and Isoxsuprine hydrochloride. Int J Biol Macromol. 2020 Jun 1;152:126-136. doi: 10.1016/j.ijbiomac.2020.02.064. Epub 2020 Feb 8. PMID: 32045611.

6: Shahraki S, Shiri F. Binding interaction of isoxsuprine hydrochloride and levothyroxine to milk β-lactoglobulin; from the perspective of comparison. Int J Biol Macromol. 2018 Apr 1;109:576-588. doi: 10.1016/j.ijbiomac.2017.12.117. Epub 2017 Dec 21. PMID: 29275203.

7: Saad AS, Elzanfaly ES, Halim MK, Kelani KM. Comparing the predictability of different chemometric models over UV-spectral data of isoxsuprine and its toxic photothermal degradation products. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Aug 5;219:444-449. doi: 10.1016/j.saa.2019.04.064. Epub 2019 May 1. PMID: 31063959.

8: Hill JW, Thompson JF, Carter MB, Edwards BS, Sklar LA, Rosenberg GA. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7;9(5):e96761. doi: 10.1371/journal.pone.0096761. PMID: 24804769; PMCID: PMC4013073.

9: Groot MJ, Lasaroms JJ, Van Hende J, Nielen MW. Veterinary treatment of cows with isoxsuprine for a caesarian section may temporarily lead to residues in hair of both cow and calf. Drug Test Anal. 2012 Jun;4(6):515-8. doi: 10.1002/dta.272. Epub 2011 Mar 5. PMID: 21381222.

10: Elliott J. Isoxsuprine: more questions than answers. Equine Vet J. 2000 Mar;32(2):90-1. doi: 10.2746/042516400777591507. PMID: 10743962.