Hexamethonium bromide dihydrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576282

CAS#: 5187-74-6

Description: Hexamethonium bromide dihydrate is a non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant.

Chemical Structure

img
Hexamethonium bromide dihydrate
CAS# 5187-74-6
Instruction

Theoretical Analysis

MedKoo Cat#: 576282
Name: Hexamethonium bromide dihydrate
CAS#: 5187-74-6
Chemical Formula: C12H34Br2N2O2
Exact Mass: 396.10
Molecular Weight: 398.220
Elemental Analysis: C, 36.19; H, 8.61; Br, 40.13; N, 7.03; O, 8.04

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Hexamethonium bromide dihydrate

IUPAC/Chemical Name: 1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide, hydrate (1:2:2)

InChi Key: FLMOMVBGUCEQEW-UHFFFAOYSA-L

InChi Code: InChI=1S/C12H30N2.2BrH.2H2O/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2

SMILES Code: O.O.[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 398.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: AUBERT H, GAVRILESCU S. [Hexamethonium bromide in therapy of some cardiovascular diseases]. Med Interna (Bucur). 1956 Dec;8(8):1182-9. Romanian. PubMed PMID: 13418082.

2: O'Byrne PM, Thomson NC, Latimer KM, Roberts RS, Morris MM, Daniel EE, Hargreave FE. The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine. J Allergy Clin Immunol. 1985 Jul;76(1):97-103. PubMed PMID: 2861223.

3: GILMORE HR, KOPELMAN H, MCMICHAEL J, MILNE IG. The effect of hexamethonium bromide on the cardiac output and pulmonary circulation. Lancet. 1952 Nov 8;2(6741):898-902. PubMed PMID: 12991634.

4: HUNTER AR. Hexamethonium bromide. Lancet. 1950 Feb 11;1(6598):251. PubMed PMID: 15403290.

5: Sun HZ, Zhao SZ, Ai HB. Microinjection of l-glutamate into the nucleus ambiguus partially inhibits gastric motility through the NMDA receptor - nitric oxide pathway. Can J Physiol Pharmacol. 2014 Jun;92(6):455-9. doi: 10.1139/cjpp-2013-0413. Epub 2014 Apr 3. PubMed PMID: 24830549.