Norzimelidine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413336

CAS#: 56775-85-0

Description: Norzimelidine is a pharmacologically active N-demethylated metabolite of zimelidine.

Chemical Structure

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Norzimelidine
CAS# 56775-85-0
Instruction

Theoretical Analysis

MedKoo Cat#: 413336
Name: Norzimelidine
CAS#: 56775-85-0
Chemical Formula: C15H15BrN2
Exact Mass: 302.04
Molecular Weight: 303.200
Elemental Analysis: C, 59.42; H, 4.99; Br, 26.35; N, 9.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Norzimelidine; CPP199; CPP-199; CPP 199

IUPAC/Chemical Name: 2-Propen-1-amine, 3-(4-bromophenyl)-N-methyl-3-(3-pyridinyl)-

InChi Key: AZFZKANGXPSDEA-NVNXTCNLSA-N

InChi Code: InChI=1S/C15H15BrN2/c1-17-10-8-15(13-3-2-9-18-11-13)12-4-6-14(16)7-5-12/h2-9,11,17H,10H2,1H3/b15-8-

SMILES Code: CNC/C=C(C1=CC=C(Br)C=C1)\C2=CC=CN=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 303.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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1: Caillé G, Kouassi E, de Montigny C. Pharmacokinetic study of zimelidine using a new GLC method. Clin Pharmacokinet. 1983 Nov-Dec;8(6):530-40. doi: 10.2165/00003088-198308060-00004. PMID: 6228368.

2: Harms HH. The antidepressant agents desipramine, fluoxetine, fluvoxamine and norzimelidine inhibit uptake of [3H]noradrenaline and [3H]5-hydroxytryptamine in slices of human and rat cortical brain tissue. Brain Res. 1983 Sep 19;275(1):99-104. doi: 10.1016/0006-8993(83)90421-3. PMID: 6226337.

3: Pawłowski L, Mazela H. Norzimelidine, a metabolite of a highly selective 5-hydroxytryptamine uptake inhibitor, can inhibit the uptake of noradrenaline in-vivo. J Pharm Pharmacol. 1984 Dec;36(12):855-8. doi: 10.1111/j.2042-7158.1984.tb04896.x. PMID: 6151986.

4: Love BL, Moore RG, Thomas J, Chaturvedi S. Pharmacokinetics of zimelidine in humans--plasma levels and urinary excretion of zimelidine and norzimelidine after intravenous and oral administration of zimelidine. Eur J Clin Pharmacol. 1981;20(2):135-9. doi: 10.1007/BF00607150. PMID: 6455297.

5: Emanuelsson B. Quantitation of zimelidine and norzimelidine in plasma using high-performance liquid chromatography. J Chromatogr. 1978 Jul 1;146(1):113-7. doi: 10.1016/s0378-4347(00)81295-5. PMID: 670347.

6: Brown D, Scott DH, Scott DB, Meyer M, Westerlund D, Lundström J. Pharmacokinetics of zimelidine. Systemic availability of zimelidine and norzimelidine in human volunteers. Eur J Clin Pharmacol. 1980 Feb;17(2):111-6. doi: 10.1007/BF00562618. PMID: 6445274.

7: Montgomery SA, Montgomery DB, McAuley R, Rani SJ, Roy D. Profile of antidepressant action of zimelidine and norzimelidine compared with amitriptyline. Adv Biochem Psychopharmacol. 1982;32:35-42. PMID: 6211942.

8: Calil HM, Jostell KG, Cowdry RW, Potter WZ. Zimelidine and norzimelidine protein binding measured by equilibrium dialysis and cerebrospinal fluid. Clin Pharmacol Ther. 1982 Apr;31(4):522-7. doi: 10.1038/clpt.1982.70. PMID: 6460587.

9: Hansen LB, Thomsen IS, Vestergård P, Larsen NE, Hvidberg EF. Plasma levels of zimelidine and norzimelidine in endogenous depression. Psychopharmacology (Berl). 1980;69(2):157-60. doi: 10.1007/BF00427642. PMID: 6450427.

10: Humphreys CJ, Levin J, Rudnick G. Antidepressant binding to the porcine and human platelet serotonin transporters. Mol Pharmacol. 1988 Jun;33(6):657-63. PMID: 3380080.