Confertin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413261

CAS#: 60426-81-5

Description: Confertin is a pseudoguaianolide that is decahydroazuleno[6,5-b]furan-2(3H)-one substituted by an oxo group at position 5, methyl groups at positions 4a and 8 and a methylidene group at position 3. It has been isolated from the aerial parts of Inula hupehensis.. It is traditionally used for the treatment of jaundice, rheumatism, dyspepsia, constipation, hypoglycemia and renal problems

Chemical Structure

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Confertin
CAS# 60426-81-5
Instruction

Theoretical Analysis

MedKoo Cat#: 413261
Name: Confertin
CAS#: 60426-81-5
Chemical Formula: C15H20O3
Exact Mass: 248.14
Molecular Weight: 248.320
Elemental Analysis: C, 72.55; H, 8.12; O, 19.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Confertin

IUPAC/Chemical Name: (3aS,4aR,7aR,8R,9aS)-4a,8-dimethyl-3-methylenedecahydroazuleno[6,5-b]furan-2,5-dione

InChi Key: DCKYPAZZUYXYTC-RJAFSOAWSA-N

InChi Code: InChI=1S/C15H20O3/c1-8-6-12-10(9(2)14(17)18-12)7-15(3)11(8)4-5-13(15)16/h8,10-12H,2,4-7H2,1,3H3/t8-,10+,11-,12+,15-/m1/s1

SMILES Code: C[C@@H]1C[C@@H]2OC(C([C@@H]2C[C@@]3([C@@H]1CCC3=O)C)=C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 248.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Dekić MS, Radulović NS, Ranđelović VN, Stojanović-Radić ZZ, Veljković BP. Essential oils and diethyl ether extracts of Serbian Xeranthemum cylindraceum and X. annum: chemical composition, antimicrobial activity, and chemotaxonomic implications. Chem Biodivers. 2015 Sep;12(9):1378-97. doi: 10.1002/cbdv.201400316. PMID: 26363882.

8: Marshall JA, Ellison RH. Letter: The stereoselective total synthesis of pseudoguaianolides: confertin. J Am Chem Soc. 1976 Jul 7;98(14):4312-3. doi: 10.1021/ja00430a051. PMID: 932363.

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10: Barquera-Lozada JE, Cuevas G. Biogenesis of sesquiterpene lactones pseudoguaianolides from germacranolides: theoretical study on the reaction mechanism of terminal biogenesis of 8-epiconfertin. J Org Chem. 2009 Jan 16;74(2):874-83. doi: 10.1021/jo802445n. PMID: 19055363.