Triphenylethylene
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MedKoo CAT#: 463953

CAS#: 58-72-0

Description: Triphenylethylene (TPE) is a simple aromatic hydrocarbon that possesses weak estrogenic activity. Its estrogenic effects were discovered in 1937. TPE was derived from structural modification of the more potent estrogen diethylstilbestrol, which is a member of the stilbestrol group of nonsteroidal estrogens.

Chemical Structure

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Triphenylethylene
CAS# 58-72-0
Instruction

Theoretical Analysis

MedKoo Cat#: 463953
Name: Triphenylethylene
CAS#: 58-72-0
Chemical Formula: C20H16
Exact Mass: 256.13
Molecular Weight: 256.348
Elemental Analysis: C, 93.71; H, 6.29

Price and Availability

Size Price Availability Quantity
10mg USD -2 2 Weeks
25mg USD -2 2 Weeks
50mg USD -2 2 Weeks
100mg USD -2 2 Weeks
200mg USD -2 2 Weeks
500mg USD -2 2 Weeks
1g USD -2 2 Weeks
2g USD -2 2 Weeks
5g USD 220 2 Weeks
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Synonym: Triphenylethene; Triphenylethylene; NSC 17535; NSC17535; NSC-17535; TPE;

IUPAC/Chemical Name: ethene-1,1,2-triyltribenzene

InChi Key: MKYQPGPNVYRMHI-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H16/c1-4-10-17(11-5-1)16-20(18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-16H

SMILES Code: C(/c1ccccc1)(c2ccccc2)=C/c3ccccc3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 256.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Abderrahman B, Maximov PY, Curpan RF, Fanning SW, Hanspal JS, Fan P, Foulds CE, Chen Y, Malovannaya A, Jain A, Xiong R, Greene GL, Tonetti DA, Thatcher GRJ, Jordan VC. Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Mol Cancer Ther. 2021 Jan;20(1):11-25. doi: 10.1158/1535-7163.MCT-20-0563. Epub 2020 Nov 11. PMID: 33177154; PMCID: PMC7790886.

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8: Chauhan N, Maher DM, Yallapu MM, B Hafeez B, Singh MM, Chauhan SC, Jaggi M. A triphenylethylene nonsteroidal SERM attenuates cervical cancer growth. Sci Rep. 2019 Jul 29;9(1):10917. doi: 10.1038/s41598-019-46680-0. PMID: 31358785; PMCID: PMC6662837.

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14: Liu F, Tao Y, Li J, Liu H, He X, Du C, Tang X, Lu P. Efficient Non-doped Blue Fluorescent Organic Light-Emitting Diodes Based on Anthracene- Triphenylethylene Derivatives. Chem Asian J. 2019 Apr 1;14(7):1004-1012. doi: 10.1002/asia.201801867. Epub 2019 Feb 20. PMID: 30680943.

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20: Li L, Wang L, Tang H, Cao D. A facile synthesis of novel near-infrared pyrrolopyrrole aza-BODIPY luminogens with aggregation-enhanced emission characteristics. Chem Commun (Camb). 2017 Jul 20;53(59):8352-8355. doi: 10.1039/c7cc04568a. PMID: 28696443.