OM99-2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575907

CAS#: 314266-76-7

Description: OM99-2 is an eight-residue Memapsin 2 and Beta-Secretase inhibitor.

Chemical Structure

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OM99-2
CAS# 314266-76-7
Instruction

Theoretical Analysis

MedKoo Cat#: 575907
Name: OM99-2
CAS#: 314266-76-7
Chemical Formula: C41H64N8O14
Exact Mass: 892.45
Molecular Weight: 893.000
Elemental Analysis: C, 55.15; H, 7.22; N, 12.55; O, 25.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: OM99-2; OM 99-2; OM-99-2

IUPAC/Chemical Name: (2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-17-(2-amino-2-oxoethyl)-2-benzyl-5-(2-carboxyethyl)-13-hydroxy-14-isobutyl-20-isopropyl-8,11-dimethyl-4,7,10,16,19,22-hexaoxo-3,6,9,15,18,21-hexaazahexacosanedioic acid

InChi Key: NIOCOJFPGCXNKL-ZKZXETMPSA-N

InChi Code: 1S/C41H64N8O14/c1-20(2)16-27(46-39(60)28(19-31(43)51)47-40(61)34(21(3)4)49-37(58)25(42)12-14-32(52)53)30(50)17-22(5)35(56)44-23(6)36(57)45-26(13-15-33(54)55)38(59)48-29(41(62)63)18-24-10-8-7-9-11-24/h7-11,20-23,25-30,34,50H,12-19,42H2,1-6H3,(H2,43,51)(H,44,56)(H,45,57)(H,46,60)(H,47,61)(H,48,59)(H,49,58)(H,52,53)(H,54,55)(H,62,63)/t22-,23+,25+,26+,27+,28+,29+,30+,34+/m1/s1

SMILES Code: CC(C)C[C@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 893.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Hu B, Xiong B, Qiu BY, Li X, Yu HP, Xiao K, Wang X, Li J, Shen JK. Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to beta-secretase. Acta Pharmacol Sin. 2006 Dec;27(12):1586-93. doi: 10.1111/j.1745-7254.2006.00432.x. PMID: 17112413.

2. Hong L, Turner RT 3rd, Koelsch G, Ghosh AK, Tang J. Memapsin 2 (beta-secretase) as a therapeutic target. Biochem Soc Trans. 2002 Aug;30(4):530-4. doi: 10.1042/bst0300530. PMID: 12196130.

3. Turner RT 3rd, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh AK, Tang J. Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design. Biochemistry. 2001 Aug 28;40(34):10001-6. doi: 10.1021/bi015546s. Erratum in: Biochemistry 2001 Oct 9;40(40):12230. Castenheira, P [corrected to Castanheira, P]; Ghosh, A [corrected to Ghosh, AK]. PMID: 11513577.