WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463727
Description: FCW66 is a novel sialyltransferase inhibitor, inhibiting MDA-MB-231 cell migration.
MedKoo Cat#: 463727
Chemical Formula: C42H61N7O12
Exact Mass: 855.4378
Molecular Weight: 855.987
Elemental Analysis: C, 58.93; H, 7.18; N, 11.45; O, 22.43
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Synonym: FCW66; FCW 66; FCW-66;
IUPAC/Chemical Name: (S)-4-(((3R,5R,8R,9S,10S,13R,14S,17R)-17-((R)-1-azido-13-oxo-3,6,9,12-tetraoxaheptadecan-16-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid
InChi Key: RAEBIEPJXFNBFB-IRJVCIBLSA-N
InChi Code: InChI=1S/C42H61N7O12/c1-26(4-11-37(52)59-23-22-58-21-20-57-19-18-56-17-16-44-48-43)30-7-8-31-29-6-5-27-24-28(12-14-41(27,2)32(29)13-15-42(30,31)3)60-40(53)34(25-36(50)51)45-33-9-10-35(49(54)55)39-38(33)46-61-47-39/h9-10,26-32,34,45H,4-8,11-25H2,1-3H3,(H,50,51)/t26-,27-,28-,29+,30-,31+,32+,34+,41+,42-/m1/s1
SMILES Code: O=C(O)C[C@H](NC1=CC=C([N+]([O-])=O)C2=NON=C21)C(O[C@@H]3CC[C@]4(C)[C@@]5([H])CC[C@]6(C)[C@@H]([C@H](C)CCC(OCCOCCOCCOCCN=[N+]=[N-])=O)CC[C@@]6([H])[C@]5([H])CC[C@]4([H])C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 855.987 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Fu CW, Tsai HE, Chen WS, Chang TT, Chen CL, Hsiao PW, Li WS. Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis. J Med Chem. 2020 Dec 28. doi: 10.1021/acs.jmedchem.0c01477. Epub ahead of print. PMID: 33371679.